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Cell-cell metabolit...
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
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- Correia-Melo, Clara (author)
- University Of Cambridge,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,The Francis Crick Institute
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- Kamrad, Stephan (author)
- The Francis Crick Institute
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- Tengölics, Roland (author)
- Magyar Tudomanyos Akademia,Hungarian Academy of Sciences
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- Messner, Christoph B. (author)
- The Francis Crick Institute,Universität Zürich,University of Zürich
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- Trebulle, Pauline (author)
- The Francis Crick Institute,University Of Oxford
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- Townsend, St John (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,The Francis Crick Institute
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- Jayasree Varma, Sreejith (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
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- Freiwald, Anja (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
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- Heineike, Benjamin M. (author)
- University Of Oxford,Medical Research Council,The Francis Crick Institute
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- Campbell, Kate, 1987 (author)
- University Of Cambridge
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- Herrera-Dominguez, Lucia (author)
- The Francis Crick Institute
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- Kaur Aulakh, Simran (author)
- The Francis Crick Institute,University Of Oxford
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- Szyrwiel, Lukasz (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,The Francis Crick Institute
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- Yu, Jason S.L. (author)
- The Francis Crick Institute
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- Zelezniak, Aleksej, 1984 (author)
- Vilniaus universitetas,Vilnius University,The Francis Crick Institute,Chalmers tekniska högskola,Chalmers University of Technology
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- Demichev, Vadim (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge,The Francis Crick Institute
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- Mülleder, Michael (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,The Francis Crick Institute,University Of Cambridge
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- Papp, Balázs (author)
- Magyar Tudomanyos Akademia,Hungarian Academy of Sciences
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Alam, Mohammad Tauqeer (author)
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- Ralser, M. (author)
- The Francis Crick Institute,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Oxford,University Of Cambridge
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 186:1, s. 63-79.e21
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https://doi.org/10.1...
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Abstract
Subject headings
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- Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and signaling. Studying chronological aging in yeast, we reveal a so far overlooked metabolic property that influences aging via the exchange of metabolites. We observed that metabolites exported by young cells are re-imported by chronologically aging cells, resulting in cross-generational metabolic interactions. Then, we used self-establishing metabolically cooperating communities (SeMeCo) as a tool to increase metabolite exchange and observed significant lifespan extensions. The longevity of the SeMeCo was attributable to metabolic reconfigurations in methionine consumer cells. These obtained a more glycolytic metabolism and increased the export of protective metabolites that in turn extended the lifespan of cells that supplied them with methionine. Our results establish metabolite exchange interactions as a determinant of cellular aging and show that metabolically cooperating cells can shape the metabolic environment to extend their lifespan.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- metabolic microenvironment
- chronological aging
- eukaryotic longevity
- metabolite exchange interactions
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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- By the author/editor
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Correia-Melo, Cl ...
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Kamrad, Stephan
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Tengölics, Rolan ...
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Messner, Christo ...
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Trebulle, Paulin ...
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Townsend, St Joh ...
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show more...
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Jayasree Varma, ...
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Freiwald, Anja
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Heineike, Benjam ...
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Campbell, Kate, ...
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Herrera-Domingue ...
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Kaur Aulakh, Sim ...
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Szyrwiel, Lukasz
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Yu, Jason S.L.
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Zelezniak, Aleks ...
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Demichev, Vadim
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Mülleder, Michae ...
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Papp, Balázs
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Alam, Mohammad T ...
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Ralser, M.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Cell
- By the university
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Chalmers University of Technology