Importance of the environment for gestational duration variability and correlation between relatives - results from the Medical Swedish Birth Registry, 1973-2012

Modzelewska, Dominika (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology

Solé Navais, Pol (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology

Zhang, G. (author): Cincinnati Children's Hospital Medical Center,University of Cincinnati

Muglia, L. J. (author): Burroughs Wellcome Fund,University of Cincinnati,Cincinnati Children's Hospital Medical Center

Nilsson, Staffan, 1956 (author): Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, Tillämpad matematik och statistik,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Mathematical Sciences, Applied Mathematics and Statistics,Department of Laboratory Medicine

Jacobsson, Bo, 1960 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology

(creator_code:org_t)

2020-07-24
2020
English.
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 15:7 July

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Abstract Subject headings

It has been suggested that the intergenerational associations in gestational age at delivery are considerably affected by temporal changes in the environmental conditions. We explored whether changing environment affects familial resemblance of gestational age at delivery. Understanding how correlation changes in different settings allows to design better studies aimed to detect genes and environmental factors involved in the parturition process. The Swedish Medical Birth Register was used to retrieve births during 1973-2012. In total, 454,433 parent-child, 2,247,062 full sibling, 405,116 maternal half-sibling and 469,995 paternal half-sibling pairs were identified. A decreasing trend in correlation, associated with increasing age gaps, was observed among all siblings, with the largest drop for full siblings, from p = 0.32 (95% confidence interval (CI): 0.31, 0.33) for full siblings with one-year gap to p = 0.16 (95% CI: 0.10, 0.22) for full siblings with age gap above 20 years. A variation in association between full siblings born up to two years apart was observed; estimate p = 0.28 (95% CI: 0.26, 0.3) in 1973, and p = 0.36 (95% CI: 0.33, 0.38) in 2012. Observed variability in the association in gestational age at delivery between the relatives with respect to their birth year or age gap suggests the existence of temporally changing environmental factors.

By the author/editor: Modzelewska, Dom ...; Solé Navais, Pol; Zhang, G.; Muglia, L. J.; Nilsson, Staffan ...; Jacobsson, Bo, 1 ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

By the university: Chalmers University of Technology; University of Gothenburg

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