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Association between...
Association between gut health and gut microbiota in a polluted environment
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- Jernfors, Toni (author)
- Jyväskylän Yliopisto,University of Jyväskylä
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- Lavrinienko, Anton (author)
- Jyväskylän Yliopisto,University of Jyväskylä,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Vareniuk, Igor (author)
- Taras Shevchenko National University of Kyiv
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- Landberg, Rikard, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Fristedt, Rikard, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Tkachenko, Olena (author)
- Taras Shevchenko National University of Kyiv
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- Taskinen, Sara (author)
- Jyväskylän Yliopisto,University of Jyväskylä
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Tukalenko, Eugene (author)
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- Mappes, Tapio (author)
- Jyväskylän Yliopisto,University of Jyväskylä
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- Watts, Phillip C. (author)
- Jyväskylän Yliopisto,University of Jyväskylä
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 914
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https://doi.org/10.1...
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Abstract
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- Animals host complex bacterial communities in their gastrointestinal tracts, with which they share a mutualistic interaction. The numerous effects these interactions grant to the host include regulation of the immune system, defense against pathogen invasion, digestion of otherwise undigestible foodstuffs, and impacts on host behaviour. Exposure to stressors, such as environmental pollution, parasites, and/or predators, can alter the composition of the gut microbiome, potentially affecting host-microbiome interactions that can be manifest in the host as, for example, metabolic dysfunction or inflammation. However, whether a change in gut microbiota in wild animals associates with a change in host condition is seldom examined. Thus, we quantified whether wild bank voles inhabiting a polluted environment, areas where there are environmental radionuclides, exhibited a change in gut microbiota (using 16S amplicon sequencing) and concomitant change in host health using a combined approach of transcriptomics, histological staining analyses of colon tissue, and quantification of short-chain fatty acids in faeces and blood. Concomitant with a change in gut microbiota in animals inhabiting contaminated areas, we found evidence of poor gut health in the host, such as hypotrophy of goblet cells and likely weakened mucus layer and related changes in Clca1 and Agr2 gene expression, but no visible inflammation in colon tissue. Through this case study we show that inhabiting a polluted environment can have wide reaching effects on the gut health of affected animals, and that gut health and other host health parameters should be examined together with gut microbiota in ecotoxicological studies.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Ecotoxicology
- Transcriptomics
- Microbiome
- Radionuclides
- Habitat degradation
- Histology
Publication and Content Type
- art (subject category)
- ref (subject category)
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Jernfors, Toni
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Lavrinienko, Ant ...
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Vareniuk, Igor
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Landberg, Rikard ...
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Fristedt, Rikard ...
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Tkachenko, Olena
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show more...
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Taskinen, Sara
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Tukalenko, Eugen ...
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Mappes, Tapio
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Watts, Phillip C ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Chalmers University of Technology