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Water transport and...
Water transport and absorption in pharmaceutical tablets – a numerical study
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- Vaitukaitis, Povilas (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Maggiolo, Dario, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Remmelgas, Johan (author)
- AstraZeneca R&D Mölndal
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- Abrahmsén-Alami, Susanna (author)
- AstraZeneca R&D Mölndal
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- Bernin, Diana, 1979 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Siiskonen, Maria Daniela Irene, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Malmqvist, Johan, 1964 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sasic, Srdjan, 1968 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sardina, Gaetano, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2019-12-16
- 2020
- English.
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In: Meccanica. - : Springer Science and Business Media LLC. - 1572-9648 .- 0025-6455. ; 55:2, s. 421-433
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Abstract
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- The quality of a coated pharmaceutical tablet can be strongly affected by the interactions of water droplets with the porous substrate during processes such as coating process. Three different mechanisms co-exist in the coating process: water spreading, absorption and evaporation. Disentangling the fundamental understanding of these phenomena can therefore be crucial for achieving a higher quality of the products (e.g. a longer shelf-life of the tablets) and for controlling the efficiency of the process. This paper aims to investigate the spreading and absorption mechanisms after droplet impingement on a tablet using a Lattice-Boltzmann methodology. Our numerical results (droplet height and spreading, penetration depth and absorbed volume) are in a good agreement with experimental data and numerical simulations available in the literature. In particular, the spreading phase is characterised by the capillary spreading time scale, as confirmed by previous studies. In contrast to previous studies, we find that the absorption process begins at times shorter than the capillary spreading time but with a different power-law in the absorbed volume. We explain this behaviour through a modified Washburn law that takes into account three-dimensional effects. Our data can be used as a benchmark to test novel mathematical models.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Farmaceutisk synteskemi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Pharmaceutical Chemistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Kemiska processer (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Chemical Process Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Strömningsmekanik och akustik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Fluid Mechanics and Acoustics (hsv//eng)
Keyword
- Porous tablets
- Pharmaceutical coating
- Droplet impact
- Absorption
- Mathematical modelling
Publication and Content Type
- art (subject category)
- ref (subject category)
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Vaitukaitis, Pov ...
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Maggiolo, Dario, ...
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Remmelgas, Johan
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Abrahmsén-Alami, ...
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Bernin, Diana, 1 ...
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Siiskonen, Maria ...
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Malmqvist, Johan ...
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Sasic, Srdjan, 1 ...
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Sardina, Gaetano ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
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and Pharmaceutical C ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
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and Chemical Process ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Mechanical Engin ...
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and Fluid Mechanics ...
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Meccanica
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Chalmers University of Technology