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Light-Regulated rel...
Light-Regulated release of liposomes from phospholipid membranes via photoresponsive polymer-DNA conjugates
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- Benkoski, Jason J., 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Jesorka, Aldo, 1967 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Edvardsson, Malin, 1973 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Höök, Fredrik, 1966 (author)
- Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-6848 .- 1744-683X. ; 2:8, s. 710-715
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Abstract
Subject headings
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- A method for releasing tethered liposomes from a supported lipid bilayer in response to a light stimulus is described. The tethering is accomplished through the hybridization of end-functionalized DNA that resides on both the supported lipid bilayer and liposome surfaces. Normally consisting of cholesterol or lipid tails, the end group is replaced in this study by a photoresponsive polymer that partitions into lipid bilayers at physiological pH. When exposed to UV light, it undergoes excited state proton transfer with water. The ensuing increase in polarity increases the solubility of the polymer in the aqueous phase. Quartz crystal microbalance with dissipation monitoring (QCM-D) and fluorescence microscopy have been used to record both the construction of the vesicle assembly and the subsequent response to UV light. It is found that the critical flow rate for vesicle release is reduced when buffer flow is performed in conjunction with UV exposure. © The Royal Society of Chemistry 2006.
Subject headings
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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