SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:research.chalmers.se:bf60effa-72b0-4978-b537-678280dec908"
 

Search: onr:"swepub:oai:research.chalmers.se:bf60effa-72b0-4978-b537-678280dec908" > Diet-rich in wheat ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Diet-rich in wheat bran modulates tryptophan metabolism and AhR/IL-22 signalling mediated metabolic health and gut dysbacteriosis: A novel prebiotic-like activity of wheat bran

Yan, Tao (author)
Shaanxi Normal University
Shi, Lin, 1988 (author)
Shaanxi Normal University,Chalmers tekniska högskola,Chalmers University of Technology
Liu, Tianqi (author)
Shaanxi Normal University
show more...
Zhang, Xiangnan (author)
Shaanxi Normal University
Yang, Minmin (author)
Shaanxi Normal University
Peng, Wen (author)
Qinghai University
Sun, Xiaomin (author)
Yan, Lijing (author)
Dai, Xiaoshuang (author)
BGI Institute of Applied Agriculture
Yang, Xinbing (author)
Shaanxi Normal University
show less...
 (creator_code:org_t)
Elsevier BV, 2023
2023
English.
In: Food Research International. - : Elsevier BV. - 0963-9969 .- 1873-7145. ; 163
Related links:
https://doi.org/10.1...
show more...
https://research.cha...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Tryptophan metabolism has shown to involve in pathogenesis of various metabolic diseases. Gut microbiota-orientated diets hold great potentials to improve metabolic health via regulating tryptophan metabolism. The present study showed that the 6-week high fat diet (HFD) disturbed tryptophan metabolism accompanied with gut dysbacteriosis, also influenced the dietary tryptophan induced changes in cecum microbiome and serum metabolome in mice. The colonic expressions of aryl hydrocarbon receptor (AhR) and interleukin-22 (IL-22) were significantly reduced in mice fed on HFD. Notably, a diet- rich in wheat bran effectively inhibited transformation of tryptophan to kynurenine-pathway metabolites, while increased melatonin and microbial catabolites, i.e. indole-3-propionic acid, indole-3-acetaldehyde and 5-hydroxy-indole-3-acetic acid. Such regulatory effects were accompanied with reduced fasting glucose and total triglycerides, and promoted AhR and IL-22 levels in HFD mice. Wheat bran increased the abundance of health promoting bacteria (e.g., Akkermansia and Lactobacillus), which were significantly correlated with tryptophan derived indolic metabolites. Additionally, beneficial modulatory effects of wheat bran on indolic metabolites in associations with gut dysbacteriosis from type 2 diabetes patients were confirmed in vitro fecal fermentation experiment. Our study proves the detrimental effects of HFD induced gut dysbacteriosis on tryptophan metabolism that may influence immune modulation, and provides novel insights in the mechanisms by which wheat bran could induce health benefits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

Indole derivatives
Wheat bran
IL-22 signalling
Tryptophan metabolism
Gut microbiota
AhR signalling

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view