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New characterizatio...
New characterization measures of pore shape and connectivity applied to coatings used for controlled drug release
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- Eriksson Barman, Sandra, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden; University of Gothenburg, Sweden
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- Fager, Cecilia, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden; University of G
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- Röding, Magnus, 1984 (author)
- RISE,Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Jordbruk och livsmedel,Chalmers University of Technology, Sweden; University of Gothenburg, Sweden
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- Lorén, Niklas, 1970 (author)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden; University of G
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- Corswant, Christian von (author)
- AstraZeneca AB,AstraZeneca, Sweden
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- Olsson, Eva, 1960 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden; University of G
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- Bolin, David, 1983 (author)
- King Abdullah University of Science and Technology (KAUST),King Abdullah University of Science and Technology, Saudi Arabia
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- Rootzen, Holger, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden; University of Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Journal of Pharmaceutical Sciences. - : Elsevier BV. - 1520-6017 .- 0022-3549. ; 110:7, s. 2753-2764
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Abstract
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- Pore geometry characterization-methods are important tools for understanding how pore structure influences properties such as transport through a porous material. Bottlenecks can have a large influence on transport and related properties. However, existing methods only catch certain types of bottleneck effects caused by variations in pore size. We here introduce a new measure, geodesic channel strength, which captures a different type of bottleneck effect caused by many paths coinciding in the same pore. We further develop new variants of pore size measures and propose a new way of visualizing 3-D characterization results using layered images. The new measures together with existing measures were used to characterize and visualize properties of 3-D FIB-SEM images of three leached ethyl-cellulose/hydroxypropyl-cellulose films. All films were shown to be anisotropic, and the strongest anisotropy was found in the film with lowest porosity. This film had very tortuous paths and strong geodesic channel-bottlenecks, while the paths through the other two films were relatively straight with well-connected pore networks. The geodesic channel strength was shown to give important new visual and quantitative insights about connectivity, and the new pore size measures provided useful information about anisotropies and inhomogeneities in the pore structures. The methods have been implemented in the freely available software MIST.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Pappers-, massa- och fiberteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Paper, Pulp and Fiber Technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Eriksson Barman, ...
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Fager, Cecilia, ...
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Röding, Magnus, ...
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Lorén, Niklas, 1 ...
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Corswant, Christ ...
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Olsson, Eva, 196 ...
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Bolin, David, 19 ...
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Rootzen, Holger, ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
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and Paper Pulp and F ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
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and Polymer Technolo ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Materials Chemis ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Mathematics
- Articles in the publication
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Journal of Pharm ...
- By the university
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Chalmers University of Technology
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University of Gothenburg
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RISE