Search: onr:"swepub:oai:research.chalmers.se:c6ae3f58-7e62-4c4d-ae9c-cbc3a0eade5f" >
Nutritional prefere...
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies
-
- Tramontano, Melanie (author)
- European Molecular Biology Laboratory
-
- Andrejev, Sergej (author)
- European Molecular Biology Laboratory
-
- Pruteanu, Mihaela (author)
- Humboldt-Universität zu Berlin,Humboldt University of Berlin,European Molecular Biology Laboratory
-
show more...
-
- Klünemann, Martina (author)
- European Molecular Biology Laboratory
-
- Kuhn, Michael (author)
- European Molecular Biology Laboratory
-
- Galardini, Marco (author)
- Wellcome Trust
-
- Jouhten, Paula, 1978 (author)
- European Molecular Biology Laboratory
-
- Zelezniak, Aleksej, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,European Molecular Biology Laboratory
-
- Zeller, Georg (author)
- European Molecular Biology Laboratory
-
- Bork, Peer (author)
- European Molecular Biology Laboratory,Julius-Maximilians Universität Würzburg,University of Würzburg,Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine
-
- Typas, Athanasios (author)
- European Molecular Biology Laboratory
-
- Patil, K. R. (author)
- European Molecular Biology Laboratory
-
show less...
-
(creator_code:org_t)
- 2018-03-19
- 2018
- English.
-
In: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 3:4, s. 514-522
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://research.cha...
-
show less...
Abstract
Subject headings
Close
- Bacterial metabolism plays a fundamental role in gut microbiota ecology and host-microbiome interactions. Yet the metabolic capabilities of most gut bacteria have remained unknown. Here we report growth characteristics of 96 phylogenetically diverse gut bacterial strains across 4 rich and 15 defined media. The vast majority of strains (76) grow in at least one defined medium, enabling accurate assessment of their biosynthetic capabilities. These do not necessarily match phylogenetic similarity, thus indicating a complex evolution of nutritional preferences. We identify mucin utilizers and species inhibited by amino acids and short-chain fatty acids. Our analysis also uncovers media for in vitro studies wherein growth capacity correlates well with in vivo abundance. Further value of the underlying resource is demonstrated by correcting pathway gaps in available genome-scale metabolic models of gut microorganisms. Together, the media resource and the extracted knowledge on growth abilities widen experimental and computational access to the gut microbiota.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Tramontano, Mela ...
-
Andrejev, Sergej
-
Pruteanu, Mihael ...
-
Klünemann, Marti ...
-
Kuhn, Michael
-
Galardini, Marco
-
show more...
-
Jouhten, Paula, ...
-
Zelezniak, Aleks ...
-
Zeller, Georg
-
Bork, Peer
-
Typas, Athanasio ...
-
Patil, K. R.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Microbiology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Computer and Inf ...
-
and Bioinformatics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
- Articles in the publication
-
Nature Microbiol ...
- By the university
-
Chalmers University of Technology