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Fatty acids in mult...
Fatty acids in multiple circulating lipid fractions reflects the composition of liver triglycerides in humans
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- Rosqvist, Fredrik, 1985- (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Institutionen för medicinska vetenskaper
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- Fridén, Michael (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Vessby, Johan, 1972- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Hockings, Paul, 1956 (author)
- Antaros Medical AB,Chalmers tekniska högskola,Chalmers University of Technology,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.;Chalmers Univ Technol, MedTech West, Gothenburg, Sweden.
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- Hulthe, Johannes, 1970 (author)
- Antaros Medical AB,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.
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- Gummesson, Anders, 1973 (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Clin Genet & Genom, Reg Vastra Gotaland, Gothenburg, Sweden.
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- Niessen, Heiko G. (author)
- Boehringer Ingelheim Pharma GmbH,Boehringer Ingelheim Pharma GmbH & Co KG, Dept Translat Med & Clin Pharmacol, Biberach, Germany.
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- Schultheis, Christian (author)
- Boehringer Ingelheim Pharma GmbH,Boehringer Ingelheim Pharma GmbH & Co KG, Dept Translat Med & Clin Pharmacol, Biberach, Germany.
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- Wanders, Alkwin (author)
- Aalborg Universitet,Aalborg University,Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
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- Ahlstrom, Hakan (author)
- Uppsala universitet,Radiologi,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.;Uppsala Univ, Dept Surg Sci, Radiol, Uppsala, Sweden.
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- Rorsman, Fredrik, Docent, 1960- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Geriatrik,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Clinical Nutrition. - : Elsevier BV. - 1532-1983 .- 0261-5614. ; 41:4, s. 805-809
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Abstract
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- Background and aims: Fatty acids (e.g. 16:1n-7) and desaturase indices (e.g. stearoyl-CoA desaturase, SCD) in plasma cholesteryl esters (CE) and phospholipids (PL) are used as biomarkers of dietary fat quality and lipid metabolism and are associated with disease outcomes. Endogenously produced circulating fatty acids are believed to reflect composition of the liver, yet little data exist to support such relationship. We investigated associations between circulating fatty acids and fatty acids within the liver. Methods: Liver biopsies and blood were collected from n = 60 patients with non-alcoholic fatty liver disease. Fatty acids in CE, PL and triglycerides (TG) in plasma and liver were analyzed using gas chromatography. Associations were assessed using Spearman rank correlations. Results: Overall, fatty acids and desaturase indices in plasma PL and TG showed moderate–strong correlations with fatty acids and desaturase indices in corresponding lipid fractions in liver. For plasma CE, 16:1n-7 and SCD were correlated with 16:1n-7 and SCD in liver CE. Noteworthy, fatty acids in plasma CE and PL also showed moderate–strong correlations with fatty acids in liver TG (e.g. r = 0.82–0.87 for 16:1n-7 and r = 0.77 for SCD). Conclusion: We demonstrate that fatty acids in circulating lipid fractions, including CE, TG and PL, reflects the composition of liver TG in humans, suggesting that circulating fatty acids might be useful biomarkers for the fatty acid composition of the liver. As liver tissue is rarely available in cohort studies, our findings could enhance our understanding of plasma fatty acids as markers of hepatic lipid metabolism and their links to metabolic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Triglycerides
- Cholesteryl esters
- Phospholipids
- SCD
- NAFLD
- Fatty acids
Publication and Content Type
- art (subject category)
- ref (subject category)
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Rosqvist, Fredri ...
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Fridén, Michael
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Vessby, Johan, 1 ...
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Hockings, Paul, ...
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Hulthe, Johannes ...
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Gummesson, Ander ...
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Niessen, Heiko G ...
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Schultheis, Chri ...
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Wanders, Alkwin
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Ahlstrom, Hakan
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Rorsman, Fredrik ...
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Risérus, Ulf, 19 ...
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and Other Clinical M ...
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MEDICAL AND HEAL ...
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Clinical Nutriti ...
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Chalmers University of Technology
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Uppsala University