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Penetratin-induced ...
Penetratin-induced Aggregation and Subsequent Dissociation of Negatively Charged Phospholipid Vesicles
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- Persson, Daniel, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Thoren, Per, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nordén, Bengt, 1945 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: FEBS Letters. - 1873-3468 .- 0014-5793. ; 505:2, s. 307-312
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The interaction of the cellular delivery vector penetratin with a model system consisting of negatively charged phospholipid vesicles has been studied. Above a certain peptide to lipid molar ratio, the cationic oligopeptide induces vesicle aggregation. Interestingly, the aggregation is followed by spontaneous disaggregation, which may be related to membrane translocation of the peptide. Circular dichroism (CD) measurements indicate a conformational transition, from alpha -helix to antiparallel beta -pleated sheet, which is simultaneous with the aggregation process. The potential influence of spectroscopic artifacts on CD data due to the drastically increased turbidity during aggregation is discussed.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Keyword
- penetratin
- Antennapedia homeodomain
- vesicle aggregation
- turbidity
- artifact
- circular dichroism
Publication and Content Type
- art (subject category)
- ref (subject category)
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