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The human gut micro...
The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs
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- Palmnäs, Marie, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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- Costabile, Giuseppina (author)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Department of Clinical Medicine and Surgery, University of Naples Federico Ii, Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico Ii, Naples, Italy
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- Vetrani, Claudia (author)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Department of Clinical Medicine and Surgery, University of Naples Federico Ii, Naples, Italy
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- Åberg, Sebastian, 1991 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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- Hjalmarsson, Yommine, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Communication and Learning in Science, Chalmers University of Technology, Gothenburg, Sweden
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- Dicksved, Johan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden
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- Riccardi, Gabriele (author)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,Department of Clinical Medicine and Surgery, University of Naples Federico Ii, Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico Ii, Naples, Italy
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- Landberg, Rikard, 1981 (author)
- Umeå universitet,Avdelningen för medicin,Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 116:4, s. 862-874
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Abstract
Subject headings
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- The gut microbiota plays a fundamental role in human nutrition and metabolism and may have direct implications for type 2 diabetes and associated preconditions. An improved understanding of relations between human gut microbiota and glucose metabolism could lead to novel opportunities for type 2 diabetes prevention, but human observational studies reporting on such findings have not been extensively reviewed. Here, we review the literature on associations between gut microbiota and markers and stages of glucose dysregulation and insulin resistance in healthy adults and in adults with metabolic disease and risk factors. We present the current evidence for identified key bacteria and their potential roles in glucose metabolism independent of overweight, obesity, and metabolic drugs. We provide support for SCFAs mediating such effects and discuss the role of diet, as well as metabolites derived from diet and gut microbiota interactions. From 5983 initially identified PubMed records, 45 original studies were eligible and reviewed. alpha Diversity and 45 bacterial taxa were associated with selected outcomes. Six taxa were most frequently associated with glucose metabolism: Akkermansia muciniphila, Bifidobacterium longum, Clostridium leptum group, Faecalibacterium prausnitzii, and Faecalibacterium (inversely associated) and Dorea (directly associated). For Dorea and A. muciniphila, associations were independent of metabolic drugs and body measures. For A. muciniphila and F. prausnitzii, limited evidence supported SCFA mediation of potential effects on glucose metabolism. We conclude that observational studies applying metagenomics sequencing to identify species-level relations are warranted, as are studies accounting for confounding factors and investigating SCFA and postprandial glucose metabolism. Such advances in the field will, together with mechanistic and prospective studies and investigations into diet-gut microbiota interactions, have the potential to bring critical insight into roles of gut microbiota and microbial metabolites in human glucose metabolism and to contribute toward the development of novel prevention strategies for type 2 diabetes, including precision nutrition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- insulin resistance
- microbial metabolites
- type 2 diabetes prevention
- short-chain fatty acids
- precision nutrition
- humans
- diet-gut microbiota interactions
- prediabetes
- gut microbiota
- glucose metabolism
Publication and Content Type
- art (subject category)
- ref (subject category)
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