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A unified model of ...
A unified model of protein dynamics
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- Frauenfelder, H. (author)
- Los Alamos National Laboratory
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- Chen, G. (author)
- Los Alamos National Laboratory
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- Berendzen, J (author)
- Los Alamos National Laboratory
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- Fenimore, P. W. (author)
- Los Alamos National Laboratory
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- Jansson, Helen, 1964 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- McMahon, B.H. (author)
- Los Alamos National Laboratory
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- Mihut-Stroe, I (author)
- Worcester Polytechnic Institute
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- Swenson, Jan, 1966 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Young, R. D. (author)
- Northern Arizona University
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(creator_code:org_t)
- 2009-03-31
- 2009
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:13, s. 5129-5134
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Abstract
Subject headings
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- Protein functions require conformational motions. We show here that the dominant conformational motions are slaved by the hydration shell and the bulk solvent. The protein contributes the structure necessary for function. We formulate a model that is based on experiments, insights from the physics of glass-forming liquids, and the concepts of a hierarchically organized energy landscape. To explore the effect of external fluctuations on protein dynamics, we measure the fluctuations in the bulk solvent and the hydration shell with broadband dielectric spectroscopy and compare them with internal fluctuations measured with the Mossbauer effect and neutron scattering. The result is clear. Large-scale protein motions are slaved to the fluctuations in the bulk solvent. They are controlled by the solvent viscosity, and are absent in a solid environment. Internal protein motions are slaved to the beta fluctuations of the hydration shell, are controlled by hydration, and are absent in a dehydrated protein. The model quantitatively predicts the rapid increase of the mean-square displacement above approximate to 200 K, shows that the external beta fluctuations determine the temperature- and time-dependence of the passage of carbon monoxide through myoglobin, and explains the nonexponential time dependence of the protein relaxation after photodissociation.
Subject headings
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Keyword
- beta process
- solvent
- hydration
- dielectric
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Frauenfelder, H.
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Chen, G.
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Berendzen, J
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Fenimore, P. W.
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Jansson, Helen, ...
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McMahon, B.H.
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show more...
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Mihut-Stroe, I
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Swenson, Jan, 19 ...
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Young, R. D.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Condensed Matter ...
- Articles in the publication
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Proceedings of t ...
- By the university
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Chalmers University of Technology