Search: onr:"swepub:oai:research.chalmers.se:cfd6ac90-d3ee-4c4e-9106-65d041343580" >
Calcineurin stimula...
Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy
-
- Chawla, Srishti, 1986 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Biomedicine
-
- Ahmadpour, Doryaneh, 1973 (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Schneider, Kara (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Biomedicine
-
show more...
-
- Kumar, Navinder, 1988 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Biomedicine
-
- Fischbach, Arthur (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
-
- Molin, Mikael, 1973 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Nyström, Thomas, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för biomedicin,Centre for Ageing and Health (Agecap),Institute of Biomedicine
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Cell Communication and Signaling. - 1478-811X. ; 21:1
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- The calcium-responsive phosphatase, calcineurin, senses changes in Ca2+ concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factor CRZ1 triggered the formation of chaperone Hsp100p (Hsp104p)-associated protein aggregates in Saccharomyces cerevisiae. Furthermore, calcineurin inactivation aggravated α-Synuclein-related cytotoxicity. Conversely, elevated production of the calcineurin activator, Cnb1p, suppressed protein aggregation and cytotoxicity associated with the familial Parkinson’s disease-related mutant α-Synuclein A53T in a partly CRZ1-dependent manner. Activation of calcineurin boosted normal localization of both wild type and mutant α-synuclein to the plasma membrane, an intervention previously shown to mitigate α-synuclein toxicity in Parkinson’s disease models. The findings demonstrate that calcineurin signaling, and Ca2+ influx to the vacuole, limit protein quality control in non-stressed cells and may have implications for elucidating to which extent aberrant calcineurin signaling contributes to the progression of Parkinson’s disease(s) and other synucleinopathies. [MediaObject not available: see fulltext.].
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Protein aggregation
- Calcineurin
- Protein phosphatase 2B
- α-synuclein
- Protein quality control
- & alpha;-synuclein
- Calcineurin
- Protein phosphatase 2B
- Protein aggregation
- Protein quality control
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Chawla, Srishti, ...
-
Ahmadpour, Dorya ...
-
Schneider, Kara
-
Kumar, Navinder, ...
-
Fischbach, Arthu ...
-
Molin, Mikael, 1 ...
-
show more...
-
Nyström, Thomas, ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Cell Communicati ...
- By the university
-
Chalmers University of Technology
-
University of Gothenburg