The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release

Andersson, Helene,1983RISE,SP Food and Bioscience,Chalmers University of Technology, Sweden (author)

Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability.

NATURVETENSKAP Fysik Annan fysik hsv//swe
NATURAL SCIENCES Physical Sciences Other Physics Topics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomaterialvetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science hsv//eng
Pellet formulation
Controlled release
Hydroxypropyl cellulose
Phase separation
Molecular weight
Film coating
Ethyl cellulose
Controlled release; Ethyl cellulose; Film coating; Hydroxypropyl cellulose; Molecular weight; Pellet formulation; Phase separation

Häbel, Henrike,1987Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers University of Technology, Sweden(Swepub:gu)xhabhe (author)
Olsson, Anna,1985Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden(Swepub:cth)annaja (author)
Sandhagen, SofieRISE,SP Food and Bioscience,Chalmers University of Technology, Sweden (author)
von Corswant, ChristianAstraZeneca AB,AstraZeneca, Sweden (author)
Hjärtstam, Johan,1962AstraZeneca AB,AstraZeneca, Sweden (author)
Persson, Michael,1956Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden; AkzoNobel, Sweden(Swepub:cth)micper (author)
Stading, Mats,1962RISE,Structure Design,Chalmers University of Technology, Sweden(Swepub:ri)matsst@ri.se (author)
Larsson, Anette,1966Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden(Swepub:cth)anettel (author)
RISESP Food and Bioscience (creator_code:org_t)

In:International Journal of Pharmaceutics: Elsevier BV511:1, s. 223-2350378-51731873-3476

By the author/editor: Andersson, Helen ...; Häbel, Henrike, ...; Olsson, Anna, 19 ...; Sandhagen, Sofie; von Corswant, Ch ...; Hjärtstam, Johan ...; show more...; Persson, Michael ...; Stading, Mats, 1 ...; Larsson, Anette, ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Other Physics To ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

By the university: Chalmers University of Technology; University of Gothenburg; RISE

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