Search: onr:"swepub:oai:research.chalmers.se:d359a0e4-cb4b-4cc6-85ec-4988e4683e7a" >
Exercise-Mediated L...
-
Pedersen, K. S.Copenhagen University Hospital
(author)
Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
Elsevier BV,2020
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:research.chalmers.se:d359a0e4-cb4b-4cc6-85ec-4988e4683e7a
-
https://doi.org/10.1016/j.isci.2020.100978DOI
-
https://research.chalmers.se/publication/516542URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Glutamine is a central nutrient for many cancers, contributing to the generation of building blocks and energy-promoting signaling necessary for neoplastic proliferation. In this study, we hypothesized that lowering systemic glutamine levels by exercise may starve tumors, thereby contributing to the inhibitory effect of exercise on tumor growth. We demonstrate that limiting glutamine availability, either pharmacologically or physiologically by voluntary wheel running, significantly attenuated the growth of two syngeneic murine tumor models of breast cancer and lung cancer, respectively, and decreased markers of atrophic signaling in muscles from tumor-bearing mice. In continuation, wheel running completely abolished tumor-induced loss of weight and lean body mass, independently of the effect of wheel running on tumor growth. Moreover, wheel running abolished tumor-induced upregulation of muscular glutamine transporters and myostatin signaling. In conclusion, our data suggest that voluntary wheel running preserves muscle mass by counteracting muscular glutamine release and tumor-induced atrophic signaling.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Gatto, Francesco,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatto
(author)
-
Zerahn, BoAmtssygehuset i Herlev
(author)
-
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
-
Pedersen, B. K.Copenhagen University Hospital
(author)
-
Hojman, P.Copenhagen University Hospital
(author)
-
Gehl, J.Sjællands Universitetshospital,Zealand University Hospital,Köpenhamns universitet,University of Copenhagen
(author)
-
Copenhagen University HospitalChalmers tekniska högskola
(creator_code:org_t)
Related titles
-
In:iScience: Elsevier BV23:42589-0042
Internet link
Find in a library
-
iScience
(Search for host publication in LIBRIS)
To the university's database