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Lipidome changes du...
Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
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Eichelmann, Fabian (author)
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Prada, Marcela (author)
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- Sellem, Laury (author)
- University of Reading
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- Jackson, Kim G. (author)
- University of Reading
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Salas-Salvadó, Jordi (author)
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- Razquin Burillo, Cristina (author)
- Universidad de Navarra,University of Navarra
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- Estruch, Ramon (author)
- Universitat de Barcelona,University of Barcelona
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Friedén, Michael (author)
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Rosqvist, Fredrik (author)
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Risérus, Ulf (author)
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- Rexrode, Kathryn (author)
- Brigham and Women's Hospital
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- Guasch-Ferré, Marta (author)
- Harvard School of Public Health, United States,Novo Nordisk Fonden,Novo Nordisk Foundation
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- Sun, Qi (author)
- Harvard School of Public Health, United States,Brigham and Women's Hospital
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- Willett, Walter C. (author)
- Harvard School of Public Health, United States
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- Martínez-González, Miguel A. (author)
- Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra
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- Lovegrove, Julie A. (author)
- University of Reading
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- Hu, Frank B. (author)
- Harvard School of Public Health, United States
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- Schulze, Matthias B. (author)
- Universität Potsdam,University of Potsdam
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- Wittenbecher, Clemens, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature Medicine. - 1078-8956 .- 1546-170X. ; In Press
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Abstract
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- Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in the MLS, reflecting better dietary fat quality, was associated with a significant reduction in the incidence of cardiovascular disease (−32%; 95% confidence interval (95% CI): −21% to −42%) and type 2 diabetes (−26%; 95% CI: −15% to −35%). We built a closely correlated simplified score, reduced MLS (rMLS), and observed that beneficial rMLS changes, suggesting improved dietary fat quality over 10 years, were associated with lower diabetes risk (odds ratio per standard deviation of 0.76; 95% CI: 0.59 to 0.98) in the Nurses’ Health Study. Furthermore, in the PREDIMED trial, an olive oil-rich Mediterranean diet intervention primarily reduced diabetes incidence among participants with unfavorable preintervention rMLS levels, suggestive of disturbed lipid metabolism before intervention. Our findings indicate that the effects of dietary fat quality on the lipidome can contribute to a more precise understanding and possible prediction of the health outcomes of specific dietary fat modifications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- By the author/editor
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Eichelmann, Fabi ...
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Prada, Marcela
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Sellem, Laury
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Jackson, Kim G.
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Salas-Salvadó, J ...
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Razquin Burillo, ...
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show more...
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Estruch, Ramon
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Friedén, Michael
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Rosqvist, Fredri ...
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Risérus, Ulf
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Rexrode, Kathryn
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Guasch-Ferré, Ma ...
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Sun, Qi
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Willett, Walter ...
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Martínez-Gonzále ...
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Lovegrove, Julie ...
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Hu, Frank B.
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Schulze, Matthia ...
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Wittenbecher, Cl ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Nature Medicine
- By the university
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Chalmers University of Technology