Search: onr:"swepub:oai:research.chalmers.se:da153fdc-6ad5-4fa3-9071-31ca18094f3b" >
Maternal dietary se...
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Barman, Malin,1983Chalmers University of Technology,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
(author)
Maternal dietary selenium intake is associated with increased gestational length and decreased risk of preterm delivery
- Article/chapterEnglish2020
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2020
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LIBRIS-ID:oai:research.chalmers.se:da153fdc-6ad5-4fa3-9071-31ca18094f3b
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https://research.chalmers.se/publication/513144URI
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https://doi.org/10.1017/S0007114519002113DOI
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https://gup.ub.gu.se/publication/286054URI
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https://lup.lub.lu.se/record/1267df3f-12a9-40d1-9193-c5f62493530aURI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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The first positive genome-wide association study on gestational length and preterm delivery showed associations with a gene involved in the selenium metabolism. In this study we examine the associations between maternal intake of selenium and selenium status with gestational length and preterm delivery in 72,025 women with singleton live births from the population based, prospective Norwegian Mother, Father and Child Cohort Study (MoBa). A self-reported, semi-quantitativ food-frequency questionnaire answered in pregnancy week 22 was used to estimate selenium intake during the first half of pregnancy. Associations were analysed with adjusted linear and cox regressions. Selenium status was assessed in whole blood collected in gestational week 17 (n=2,637). Median dietary selenium intake was 53 (IQR: 44-62) μg/day, supplements provided additionally 50 (30-75) μg/day for supplement-users (n=23,409). Maternal dietary selenium intake was significantly associated with prolonged gestational length (β per SD=0.25, 95% CI=0.07-0.43) and decreased risk for preterm delivery (n=3,618, HR per SD=0.92, 95% CI=0.87-0.98). Neither selenium intake from supplements nor maternal blood selenium status was associated with gestational length or preterm delivery. Hence, this study showed that maternal dietary selenium intake, but not intake of selenium containing supplements, during the first half of pregnancy was significantly associated with decreased risk for preterm delivery. Further investigations, preferably in the form of a large RCT, are needed to elucidate the impact of selenium on pregnancy duration.
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Brantsaeter, Anne-LiseNorwegian Institute of Public Health
(author)
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Nilsson, Staffan,1956University of Gothenburg,Chalmers University of Technology,Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Mathematical Sciences,Department of Laboratory Medicine(Swepub:gu)xnista
(author)
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Haugen, MargarethaNorwegian Institute of Public Health
(author)
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Lundh, ThomasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-tlu
(author)
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Combs, Gerald F.Jean Mayer USDA Human Nutrition Research Center on Aging,Tufts University
(author)
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Zhang, G.University of Cincinnati,University of Cincinnati College of Medicine
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Muglia, L. J.University of Cincinnati,University of Cincinnati College of Medicine
(author)
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Meltzer, Helle MNorwegian Institute of Public Health
(author)
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Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Norwegian Institute of Public Health(Swepub:gu)xjacbo
(author)
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Sengpiel, Verena,1977Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital(Swepub:gu)xsenve
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
(creator_code:org_t)
Related titles
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In:British Journal of Nutrition123:2, s. 209-2190007-11451475-2662
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Combs, Gerald F.
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Zhang, G.
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Meltzer, Helle M
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