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Identity of bla ctx...
Identity of bla ctx-m carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections
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- Karami, Nahid, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,CARe - Centrum för antibiotikaresistensforskning,Institute of Biomedicine, Department of Infectious Medicine,Centre for antibiotic resistance research, CARe
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- Kesarimangalam, Sriram, 1983 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Yazdanshenas, Shora (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Göteborgs universitet,University of Gothenburg
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- Lin, Yii Lih, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Jaén-Luchoro, Daniel (author)
- Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Centre for antibiotic resistance research, CARe,Institute of Biomedicine, Department of Infectious Medicine
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- Ekedahl, Elina (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Parameshwaran, Sanjana (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lindblom, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,CARe - Centrum för antibiotikaresistensforskning,Institute of Biomedicine, Department of Infectious Medicine,Centre for antibiotic resistance research, CARe
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- Åhrén, Christina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,CARe - Centrum för antibiotikaresistensforskning,Institute of Biomedicine, Department of Infectious Medicine,Centre for antibiotic resistance research, CARe
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- Westerlund, Fredrik, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Kk, S. (author)
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(creator_code:org_t)
- 2021-05-25
- 2021
- English.
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In: Microorganisms. - : MDPI AG. - 2076-2607. ; 9:6
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Abstract
Subject headings
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- Plasmid-mediated multidrug resistance in E. coli is becoming increasingly prevalent. Considering this global threat to human health, it is important to understand how plasmid-mediated resistance spreads. From a cohort of 123 patients with recurrent urinary tract infections (RUTI) due to extended spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL E. coli), only five events with a change of ESBL E. coli strain between RUTI episodes were identified. Their blaCTX-M encoding plasmids were compared within each pair of isolates using optical DNA mapping (ODM) and PCR-based replicon typing. Despite similar blaCTX-M genes and replicon types, ODM detected only one case with identical plasmids in the sequential ESBL E. coli strains, indicating that plasmid transfer could have occurred. For comparison, plasmids from seven patients with the same ESBL E. coli strain reoccurring in both episodes were analyzed. These plasmids (encoding blaCTX-M-3, blaCTX-M-14, and blaCTX-M-15 ) were unaltered for up to six months between recurrent infections. Thus, transmission of blaCTX-M plasmids appears to be a rare event during the course of RUTI. Despite the limited number (n = 23) of plasmids investigated, similar blaCTX-M-15 plasmids in unrelated isolates from different patients were detected, suggesting that some successful plasmids could be associated with specific strains, or are more easily transmitted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Optical DNA mapping (ODM)
- Extended-spectrum beta-lactamase (ESBL)
- E. coli
- Horizontal transfer
- Plasmids
- Recurrent urinary tract infection
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Karami, Nahid, 1 ...
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Kesarimangalam, ...
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Yazdanshenas, Sh ...
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Lin, Yii Lih, 19 ...
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Jaén-Luchoro, Da ...
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Ekedahl, Elina
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show more...
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Parameshwaran, S ...
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Lindblom, Anna
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Åhrén, Christina
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Westerlund, Fred ...
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Kk, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Microorganisms
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Chalmers University of Technology
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University of Gothenburg