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Metabolic engineeri...
Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica – A Review
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- Wang, Jinpeng (author)
- Nanjing Tech University
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- Ledesma-Amaro, R. (author)
- Imperial College of Science, Technology and Medicine
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- Wei, Yongjun (author)
- Zhengzhou University
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- Ji, Boyang, 1983 (author)
- Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology
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- Ji, Xiao Jun (author)
- Nanjing Tech University
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Bioresource Technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 313
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Abstract
Subject headings
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- Current energy security and climate change policies encourage the development and utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the sustainable production of biofuels and industrial chemicals due to their ability to accumulate high amounts of lipids. In particular, microbial lipids in the form of triacylglycerides (TAGs) produced from renewable feedstocks have attracted considerable attention because they can be directly used in the production of biodiesel and oleochemicals analogous to petrochemicals. As an oleaginous yeast that is generally regarded as safe, Yarrowia lipolytica has been extensively studied, with large amounts of data on its lipid metabolism, genetic tools, and genome sequencing and annotation. In this review, we highlight the newest strategies for increasing lipid accumulation using metabolic engineering and summarize the research advances on the overaccumulation of lipids in Y. lipolytica. Finally, perspectives for future engineering approaches are proposed.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Tvärvetenskapliga studier inom samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Social Sciences Interdisciplinary (hsv//eng)
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap -- Förnyelsebar bioenergi (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences -- Renewable Bioenergy Research (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Energisystem (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Energy Systems (hsv//eng)
Keyword
- Biodiesel
- Triacylglycerides
- Yarrowia lipolytica
- Lipid accumulation
- Metabolic engineering
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