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A Microfluidic Diluter Based on Pulse Width Flow Modulation
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- Ainla, Alar, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gözen, Irep, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Orwar, Owe, 1964 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- (creator_code:org_t)
- 2009-05-28
- 2009
- English.
- In: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 81:13, s. 5549-5556
- Journal article (peer-reviewed)
Abstract
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- We demonstrate that pulse width flow modulation (PWFM) can be used to design fasts accurate, and precise multi-stage dilution modules for microfluidic devices. The PWFM stage unit presented here yields 10-fold dilution, but several PWFM stages can be connected in series to yield higher-order dilutions. We have combined two stages in a device thus capable of diluting up to 100-fold, and we have experimentally determined a set of rules that can be conveniently utilized to design multistage diluters. Microfabrication with resist-based molds yielded geometrical channel height variances of 7% (22.9(16) mu m) with corresponding hydraulic resistance variances of similar to 20%. Pulsing frequencies, channel lengths, and flow pressures can be chosen within a wide range to establish the desired diluter properties. Finally, we illustrate the benefits of on-chip dilution in an example application where we investigate the effect of the Ca2+ concentration on a phospholipid bilayer spreading from a membrane reservoir onto a SiO2 surface. This is one of many possible applications where flexible concentration control is desirable.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- biosensors
- hydrophilic surfaces
- networks
- nanoliter-scale
- liposomes
- generation
- dynamic chemical signals
- membranes
- bilayers
- device
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- art (subject category)
- ref (subject category)
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