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Factors Explaining ...
Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans
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- Hålldin, Elin (author)
- Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU)
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- Eriksen, Anne Kirstine (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Danish Cancer Research Society Center, Denmark,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Danish Cancer Society Research Center
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- Brunius, Carl, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- da Silva, Andreia Bento (author)
- Nova University of Lisbon, Portugal,Universidade de Lisboa,University of Lisbon
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- Bronze, Maria (author)
- Nova University of Lisbon, Portugal,Instituto de Biologia Experimental e Tecnologica,Universidade de Lisboa,University of Lisbon
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- Hanhineva, K. (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Aura, Anna-Marja (author)
- Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT)
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- Landberg, Rikard, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
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- 2019-03-26
- 2019
- English.
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In: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 63:16
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Abstract
Subject headings
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- Lignans are diphenolic plant compounds with potential health modulating properties that are absorbed to the circulation and metabolized to the enterolignans enterodiol (END) and enterolactone (ENL) by gut microbiota. Epidemiological studies have inconsistently shown that a high lignan intake and circulating ENL are associated with reduced risk of breast-, prostate-, and colorectal cancer as well as cardiovascular disease and total and cause-specific mortality. Inconsistencies can be due to interpersonal variation of ENL formation or responses. The aim of this review is to identify and evaluate the impact of factors influencing variability in plasma concentrations of the main enterolignan, ENL. The main determinants of plasma ENL concentrations are intake of lignan and lignan-rich foods, composition and activity of intestinal microflora, antimicrobial use, nutrient intake, BMI, smoking, sex, and age. Composition and activity of the intestinal microbiota appear to be the most critical factor governing interpersonal variability in plasma ENL concentration followed by the use of antibiotics. Future studies with combined data from gut microbiota and metabolomics with food intake and life style data can be used to estimate the relative contribution of the different factors to ENL concentration in quantitative terms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- lignans
- determinants
- enterolactone
- plasma
- interpersonal variation
Publication and Content Type
- for (subject category)
- ref (subject category)
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