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Plasma metabolites ...
Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study
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- Schillemans, Tessa (author)
- Karolinska Institutet
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- Shi, Lin, 1988 (author)
- Shaanxi Normal University,Chalmers tekniska högskola,Chalmers University of Technology
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- Donat Vargas, Carolina (author)
- Karolinska Institutet
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- Hanhineva, Kati, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland
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- Tornevi, Andreas (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå University
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi,Umeå University
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- Koponen, Jani (author)
- Finnish Institute for Health and Welfare
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- Kiviranta, Hannu (author)
- Finnish Institute for Health and Welfare
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin,Umeå University
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- Bergdahl, Ingvar A. (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå University,Karolinska Institutet
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- Landberg, Rikard, 1981 (author)
- Umeå universitet,Avdelningen för hållbar hälsa,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Umeå University,Chalmers tekniska högskola,Chalmers University of Technology
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- Åkesson, Agneta (author)
- Karolinska Institutet
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- Brunius, Carl, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 146
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
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- Perfluoroalkyl substances (PFAS) are widespread persistent environmental pollutants. There is evidence that PFAS induce metabolic perturbations in humans, but underlying mechanisms are still unknown. In this exploratory study, we investigated PFAS-related plasma metabolites for their associations with type 2 diabetes (T2D) to gain potential mechanistic insight in these perturbations. We used untargeted LC-MS metabolomics to find metabolites related to PFAS exposures in a case-control study on T2D (n = 187 matched pairs) nested within the Västerbotten Intervention Programme cohort. Following principal component analysis (PCA), six PFAS measured in plasma appeared in two groups: 1) perfluorononanoic acid, perfluorodecanoic acid and perfluoroundecanoic acid and 2) perfluorohexane sulfonic acid, perfluorooctane sulfonic acid and perfluorooctanoic acid. Using a random forest algorithm, we discovered metabolite features associated with individual PFAS and PFAS exposure groups which were subsequently investigated for associations with risk of T2D. PFAS levels correlated with 171 metabolite features (0.16 ≤ |r| ≤ 0.37, false discovery rate (FDR) adjusted p < 0.05). Out of these, 35 associated with T2D (p < 0.05), with 7 remaining after multiple testing adjustment (FDR < 0.05). PCA of the 35 PFAS- and T2D-related metabolite features revealed two patterns, dominated by glycerophospholipids and diacylglycerols, with opposite T2D associations. The glycerophospholipids correlated positively with PFAS and associated inversely with risk for T2D (Odds Ratio (OR) per 1 standard deviation (1-SD) increase in metabolite PCA pattern score = 0.2; 95% Confidence Interval (CI) = 0.1–0.4). The diacylglycerols also correlated positively with PFAS, but they associated with increased risk for T2D (OR per 1-SD = 1.9; 95% CI = 1.3–2.7). These results suggest that PFAS associate with two groups of lipid species with opposite relations to T2D risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Nested case-control study
- Perfluoroalkyl substances
- Metabolomics
- Type 2 Diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Schillemans, Tes ...
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Shi, Lin, 1988
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Donat Vargas, Ca ...
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Hanhineva, Kati, ...
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Tornevi, Andreas
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Johansson, Ingeg ...
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show more...
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Koponen, Jani
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Kiviranta, Hannu
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Rolandsson, Olov
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Bergdahl, Ingvar ...
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Landberg, Rikard ...
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Åkesson, Agneta
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Brunius, Carl, 1 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Environment Inte ...
- By the university
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Chalmers University of Technology
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Umeå University
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Karolinska Institutet