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Plasma metabolites ...
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Schillemans, TessaKarolinska Institutet
(author)
Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier BV,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:research.chalmers.se:e41b2c7a-42ed-4a72-baeb-41ee37f5e69b
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https://research.chalmers.se/publication/520387URI
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https://doi.org/10.1016/j.envint.2020.106180DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178029URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145508788URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Perfluoroalkyl substances (PFAS) are widespread persistent environmental pollutants. There is evidence that PFAS induce metabolic perturbations in humans, but underlying mechanisms are still unknown. In this exploratory study, we investigated PFAS-related plasma metabolites for their associations with type 2 diabetes (T2D) to gain potential mechanistic insight in these perturbations. We used untargeted LC-MS metabolomics to find metabolites related to PFAS exposures in a case-control study on T2D (n = 187 matched pairs) nested within the Västerbotten Intervention Programme cohort. Following principal component analysis (PCA), six PFAS measured in plasma appeared in two groups: 1) perfluorononanoic acid, perfluorodecanoic acid and perfluoroundecanoic acid and 2) perfluorohexane sulfonic acid, perfluorooctane sulfonic acid and perfluorooctanoic acid. Using a random forest algorithm, we discovered metabolite features associated with individual PFAS and PFAS exposure groups which were subsequently investigated for associations with risk of T2D. PFAS levels correlated with 171 metabolite features (0.16 ≤ |r| ≤ 0.37, false discovery rate (FDR) adjusted p < 0.05). Out of these, 35 associated with T2D (p < 0.05), with 7 remaining after multiple testing adjustment (FDR < 0.05). PCA of the 35 PFAS- and T2D-related metabolite features revealed two patterns, dominated by glycerophospholipids and diacylglycerols, with opposite T2D associations. The glycerophospholipids correlated positively with PFAS and associated inversely with risk for T2D (Odds Ratio (OR) per 1 standard deviation (1-SD) increase in metabolite PCA pattern score = 0.2; 95% Confidence Interval (CI) = 0.1–0.4). The diacylglycerols also correlated positively with PFAS, but they associated with increased risk for T2D (OR per 1-SD = 1.9; 95% CI = 1.3–2.7). These results suggest that PFAS associate with two groups of lipid species with opposite relations to T2D risk.
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Shi, Lin,1988Shaanxi Normal University,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)shlin
(author)
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Donat Vargas, CarolinaKarolinska Institutet
(author)
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Hanhineva, Kati,1972Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland(Swepub:cth)kati
(author)
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Tornevi, AndreasUmeå universitet,Avdelningen för hållbar hälsa,Umeå University(Swepub:umu)anstoi02
(author)
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Johansson, IngegerdUmeå universitet,Institutionen för odontologi,Umeå University(Swepub:umu)injo0003
(author)
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Koponen, JaniFinnish Institute for Health and Welfare
(author)
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Kiviranta, HannuFinnish Institute for Health and Welfare
(author)
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Rolandsson, OlovUmeå universitet,Allmänmedicin,Umeå University(Swepub:umu)olro0005
(author)
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Bergdahl, Ingvar A.Umeå universitet,Avdelningen för hållbar hälsa,Umeå University,Karolinska Institutet(Swepub:umu)inbe0001
(author)
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Landberg, Rikard,1981Umeå universitet,Avdelningen för hållbar hälsa,Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Umeå University,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:umu)rila0031
(author)
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Åkesson, AgnetaKarolinska Institutet
(author)
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Brunius, Carl,1974Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)carlbru
(author)
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Karolinska InstitutetShaanxi Normal University
(creator_code:org_t)
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In:Environment International: Elsevier BV1460160-41201873-6750
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Tornevi, Andreas
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Koponen, Jani
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Kiviranta, Hannu
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