Proteomic Analysis of Cerebrospinal Fluid in a Fulminant Case of Multiple Sclerosis

Bencsik, K. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary

Rajda, C. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark

Kovacs, S. K. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary

Kaizer, L. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary

Beniczky, S. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark

Vecsei, L. (author): University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged AND Neuroscience Research Group, Hungarian Academy of Sciences, University of Szeged, Hungary

Bergquist, Jonas (author): Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab

(creator_code:org_t)

2012-06-21
2012
English.
In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 13:6, s. 7676-7693

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Abstract Subject headings

Multiple Sclerosis (MS) is a chronic disease, but in rare fulminant cases rapid progression may lead to death shortly after diagnosis. Currently there is no diagnostic test to predict disease course. The aim of this study was to identify potential biomarkers/proteins related to rapid progression. We present the case history of a 15-year-old male MS patient. Cerebrospinal fluid (CSF) was taken at diagnosis and at the time of rapid progression leading to the patient's death. Using isobaric tag labeling and nanoflow liquid chromatography in conjunction with matrix assisted laser desorption/ionization time of flight tandem mass spectrometry we quantitatively analyzed the protein content of two CSF samples from the patient with fulminant MS as well as one relapsing-remitting (RR) MS patient and one control headache patient, whose CSF analysis was normal. Seventy-eight proteins were identified and seven proteins were found to be more abundant in both fulminant MS samples but not in the RR MS sample compared to the control. These proteins are involved in the immune response, blood coagulation, cell proliferation and cell adhesion. In conclusion, in this pilot study we were able to show differences in the CSF proteome of a rapidly progressing MS patient compared to a more typical clinical form of MS and a control subject.

By the author/editor: Fuvesi, J.; Hanrieder, Jörg, ...; Bencsik, K.; Rajda, C.; Kovacs, S. K.; Kaizer, L.; show more...; Beniczky, S.; Vecsei, L.; Bergquist, Jonas; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Analytical Chemi ...

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