Search: onr:"swepub:oai:research.chalmers.se:ee2f2856-34a9-41bf-84cd-63b3ba0d0253" >
Proteomic Analysis ...
Proteomic Analysis of Cerebrospinal Fluid in a Fulminant Case of Multiple Sclerosis
-
- Fuvesi, J. (author)
- Uppsala universitet,Analytisk kemi
-
- Hanrieder, Jörg, 1980 (author)
- Uppsala universitet,Analytisk kemi
-
- Bencsik, K. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
-
show more...
-
- Rajda, C. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark
-
- Kovacs, S. K. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
-
- Kaizer, L. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
-
- Beniczky, S. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark
-
- Vecsei, L. (author)
- University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged AND Neuroscience Research Group, Hungarian Academy of Sciences, University of Szeged, Hungary
-
- Bergquist, Jonas (author)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- 2012-06-21
- 2012
- English.
-
In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 13:6, s. 7676-7693
- Related links:
-
http://publications.... (primary) (free)
-
show more...
-
https://www.mdpi.com...
-
http://www.mdpi.com/...
-
https://uu.diva-port... (primary) (Raw object)
-
https://research.cha...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Multiple Sclerosis (MS) is a chronic disease, but in rare fulminant cases rapid progression may lead to death shortly after diagnosis. Currently there is no diagnostic test to predict disease course. The aim of this study was to identify potential biomarkers/proteins related to rapid progression. We present the case history of a 15-year-old male MS patient. Cerebrospinal fluid (CSF) was taken at diagnosis and at the time of rapid progression leading to the patient's death. Using isobaric tag labeling and nanoflow liquid chromatography in conjunction with matrix assisted laser desorption/ionization time of flight tandem mass spectrometry we quantitatively analyzed the protein content of two CSF samples from the patient with fulminant MS as well as one relapsing-remitting (RR) MS patient and one control headache patient, whose CSF analysis was normal. Seventy-eight proteins were identified and seven proteins were found to be more abundant in both fulminant MS samples but not in the RR MS sample compared to the control. These proteins are involved in the immune response, blood coagulation, cell proliferation and cell adhesion. In conclusion, in this pilot study we were able to show differences in the CSF proteome of a rapidly progressing MS patient compared to a more typical clinical form of MS and a control subject.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- biomarkers
- fulminant
- protein quantification
- identification
- patterns
- autoimmune-disease
- multiple sclerosis
- csf
- lesions
- diagnosis
- vitamin-d
- protein
- resonance mass-spectrometry
- shotgun-proteomics
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Fuvesi, J.
-
Hanrieder, Jörg, ...
-
Bencsik, K.
-
Rajda, C.
-
Kovacs, S. K.
-
Kaizer, L.
-
show more...
-
Beniczky, S.
-
Vecsei, L.
-
Bergquist, Jonas
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Analytical Chemi ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
- Articles in the publication
-
International Jo ...
- By the university
-
Chalmers University of Technology
-
Uppsala University