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Profiling of sub‐lethal in vitro effects of multi‐walled carbon nanotubes reveals changes in chemokines and chemokine receptors

Keshavan, Sandeep (author)
Karolinska Institutet
Andón, Fernando Torres (author)
Karolinska Institutet,Universidade de Santiagode Compostela,Humanitas Research Hospital
Gallud, Audrey, 1988 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Karolinska Institutet
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Chen, Wei (author)
Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine,Southern University of Science and Technology
Reinert, Knut (author)
Freie Universität Berlin
Tran, Lang (author)
Institute Of Occupational Medicine
Fadeel, Bengt (author)
Karolinska Institutet
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 (creator_code:org_t)
2021-03-30
2021
English.
In: Nanomaterials. - : MDPI AG. - 2079-4991. ; 11:4
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Engineered nanomaterials are potentially very useful for a variety of applications, but studies are needed to ascertain whether these materials pose a risk to human health. Here, we studied three benchmark nanomaterials (Ag nanoparticles, TiO2 nanoparticles, and multi‐walled carbon nanotubes, MWCNTs) procured from the nanomaterial repository at the Joint Research Centre of the European Commission. Having established a sub‐lethal concentration of these materials using two human cell lines representative of the immune system and the lungs, respectively, we performed RNA sequencing of the macrophage‐like cell line after exposure for 6, 12, and 24 h. Downstream analysis of the transcriptomics data revealed significant effects on chemokine signaling pathways. CCR2 was identified as the most significantly upregulated gene in MWCNT‐exposed cells. Using multiplex assays to evaluate cytokine and chemokine secretion, we could show significant effects of MWCNTs on several chemokines, including CCL2, a ligand of CCR2. The results demonstrate the importance of evaluating sub‐lethal concentrations of nanomaterials in relevant target cells.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Chemokines
Macrophages
Nanoparticles
Transcriptomics
Multi‐walled carbon nanotubes

Publication and Content Type

art (subject category)
ref (subject category)

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