Search: onr:"swepub:oai:research.chalmers.se:f2232a27-2926-4c42-b867-21ec5e379474" >
Canonical DNA minor...
Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity
-
- Sánchez, Mateo I. (author)
- Universidade de Santiagode Compostela
-
- Rama, Gustavo (author)
- Universidade de Santiagode Compostela
-
- Calo-Lapido, Renata (author)
- Universidade de Santiagode Compostela
-
show more...
-
- Ucar, Kubra, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Lincoln, Per, 1958 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- López, Miguel Vázquez (author)
- Universidade de Santiagode Compostela
-
- Melle-Franco, Manuel (author)
- Universidade de Aveiro,University of Aveiro
-
- Mascarenãs, José L. (author)
- Universidade de Santiagode Compostela
-
- Vázquez, M. Eugenio (author)
- Universidade de Santiagode Compostela
-
show less...
-
(creator_code:org_t)
- 2019
- 2019
- English.
-
In: Chemical Science. - : Royal Society of Chemistry (RSC). - 2041-6539 .- 2041-6520. ; 10:37, s. 8668-8674
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://pubs.rsc.org...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://research.cha...
-
show less...
Abstract
Subject headings
Close
- We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Annan industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Other Industrial Biotechnology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sánchez, Mateo I ...
-
Rama, Gustavo
-
Calo-Lapido, Ren ...
-
Ucar, Kubra, 198 ...
-
Lincoln, Per, 19 ...
-
López, Miguel Vá ...
-
show more...
-
Melle-Franco, Ma ...
-
Mascarenãs, José ...
-
Vázquez, M. Euge ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biophysics
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Industrial Biote ...
-
and Other Industrial ...
- Articles in the publication
-
Chemical Science
- By the university
-
Chalmers University of Technology