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Fatty acid synthesi...
Fatty acid synthesis is required for breast cancer brain metastasis
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- Ferraro, Gino B. (author)
- Massachusetts General Hospital
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- Ali, Ahmed (author)
- Massachusetts Institute of Technology (MIT)
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- Luengo, Alba (author)
- Massachusetts Institute of Technology (MIT)
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- Kodack, David P. (author)
- Novartis Institutes for BioMedical Research,Massachusetts General Hospital
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- Deik, Amy (author)
- Massachusetts Institute of Technology (MIT)
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- Abbott, Keene L. (author)
- Massachusetts Institute of Technology (MIT)
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- Bezwada, Divya (author)
- Massachusetts General Hospital
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- Blanc, Landry (author)
- Rutgers University,Institut de Chimie et de Biologie des Membranes et des Nano-Objets (CBMN)
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- Prideaux, Brendan (author)
- The University of Texas at Austin, USA,Rutgers University
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- Jin, Xin (author)
- Massachusetts Institute of Technology (MIT)
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- Possada, Jessica M. (author)
- Brigham and Women's Hospital,Massachusetts General Hospital
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- Chen, Jiang (author)
- Massachusetts General Hospital
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- Chin, Christopher R. (author)
- Massachusetts Institute of Technology (MIT)
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- Amoozgar, Zohreh (author)
- Massachusetts General Hospital
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- Ferreira, Raphael, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Massachusetts Institute of Technology (MIT)
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- Chen, Ivy X. (author)
- Massachusetts General Hospital
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- Naxerova, Kamila (author)
- Harvard Medical School,Massachusetts General Hospital
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- Ng, Christopher (author)
- Massachusetts Institute of Technology (MIT)
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- Westermark, Anna M. (author)
- Massachusetts Institute of Technology (MIT)
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- Duquette, Mark (author)
- Massachusetts General Hospital
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- Roberge, Sylvie (author)
- Massachusetts General Hospital
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- Lindeman, Neal I. (author)
- Brigham and Women's Hospital
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- Lyssiotis, Costas A. (author)
- University of Michigan,Harvard Medical School
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Housman, David E. (author)
- Massachusetts Institute of Technology (MIT)
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- Duda, Dan G. (author)
- Massachusetts General Hospital
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- Brachtel, Elena (author)
- Harvard Medical School
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- Golub, Todd R. (author)
- Massachusetts Institute of Technology (MIT)
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- Cantley, Lewis C. (author)
- Harvard Medical School
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- Asara, John M. (author)
- Harvard Medical School
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- Davidson, Shawn M. (author)
- Massachusetts Institute of Technology (MIT),Princeton University
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- Fukumura, Dai (author)
- Massachusetts General Hospital
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- Dartois, Véronique A. (author)
- Rutgers University,Hackensack Meridian Health
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- Clish, Clary B. (author)
- Massachusetts Institute of Technology (MIT)
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- Jain, Rakesh K. (author)
- Massachusetts General Hospital
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- Vander Heiden, Matthew G. (author)
- Massachusetts Institute of Technology (MIT),Dana-Farber Cancer Institute
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(creator_code:org_t)
- 2021-04-01
- 2021
- English.
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In: Nature Cancer. - : Springer Science and Business Media LLC. - 2662-1347. ; 2:4, s. 414-428
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Ferraro, Gino B.
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Ali, Ahmed
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Luengo, Alba
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Kodack, David P.
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Deik, Amy
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Abbott, Keene L.
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show more...
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Bezwada, Divya
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Blanc, Landry
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Prideaux, Brenda ...
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Jin, Xin
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Possada, Jessica ...
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Chen, Jiang
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Chin, Christophe ...
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Amoozgar, Zohreh
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Ferreira, Raphae ...
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Chen, Ivy X.
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Naxerova, Kamila
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Ng, Christopher
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Westermark, Anna ...
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Duquette, Mark
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Roberge, Sylvie
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Lindeman, Neal I ...
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Lyssiotis, Costa ...
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Nielsen, Jens B, ...
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Housman, David E ...
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Duda, Dan G.
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Brachtel, Elena
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Golub, Todd R.
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Cantley, Lewis C ...
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Asara, John M.
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Davidson, Shawn ...
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Fukumura, Dai
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Dartois, Véroniq ...
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Clish, Clary B.
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Jain, Rakesh K.
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Vander Heiden, M ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Cancer
- By the university
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Chalmers University of Technology