Can We Use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective

Food is an integral part of human life, and the composition of our diet is an important determinant of our health and well-being. Food is also the main source of energy and nutrients for the gut microbiota, the 100 trillion cells that coexist inside us. The impact of macronutrients (protein, fat, carbohydrates, and fiber) and specific non-nutrient food components (polyphenols) will be reviewed in the context of gut microbial function and interaction with the host. Colonic microbiota provides diverse enzymatic activities differing from our own, which lead to the production of metabolites essential for key metabolic functions, including carbohydrate and amino acid metabolism. Certain gut metabolites are specific to microbial activity and confer functionalities beyond energy production, such as signalling cascades across cells, tissues, and organs. Metabolomics has proven to be a useful tool to measure the effects of food on the gut microbiota and its interaction with host metabolism.

NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
LANTBRUKSVETENSKAPER Lantbruksvetenskap, skogsbruk och fiske Livsmedelsvetenskap hsv//swe
AGRICULTURAL SCIENCES Agriculture, Forestry and Fisheries Food Science hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
Choline
Fiber
Phase II metabolism
Pathways
Digestion
Metabolism
Nutrition
Metabolomics
Whole-grain cereals
p-Cresol sulfate
Chocolate
Carnitine
Branched-chain fatty acids
Hippurate
Colon
Trimethylamine oxide
Microbiota
Indole metabolites
Food
Butyrate
Fat
Short-chain fatty acids
Protein
Phenolic and phenyl metabolites
Gut-liver
Prebiotics
Gut-brain
Intestine
Metabolomics
One carbon metabolism
Diet
Polyphenols
Gut
Carbohydrate

Ross, Alastair,1976Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)alastair (author)
Nestle S.A.Chalmers tekniska högskola (creator_code:org_t)

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Agriculture Fore ...; and Food Science

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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