Search: onr:"swepub:oai:research.chalmers.se:f873e566-cf05-4094-bbb2-c449da3aeb08" >
The Impact of Acute...
The Impact of Acute Nutritional Interventions on the Plasma Proteome
-
- Vernardis, (author)
- The Francis Crick Institute
-
- Demichev, Vadim (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
- Lemke, Oliver (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
show more...
-
- Gruening, Nana-Maria (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
- Messner, Christoph (author)
- The Francis Crick Institute
-
- White, Matt (author)
- The Francis Crick Institute
-
- Pietzner, Maik (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge
-
- Peluso, Alina (author)
- The Francis Crick Institute
-
- Collet, Tinh-Hai (author)
- Université de Genève,University of Geneva,University Of Cambridge
-
- Henning, Elana (author)
- University Of Cambridge
-
- Gille, Christoph (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
- Campbell, Archie (author)
- University of Edinburgh
-
- Hayward, Caroline (author)
- University of Edinburgh
-
- Porteous, David J. (author)
- University of Edinburgh
-
- Marioni, Riccardo E. (author)
- University of Edinburgh
-
- Muelleder, Michael (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
- Zelezniak, Aleksej, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Langenberg, Claudia (author)
- University Of Cambridge,Queen Mary University of London,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
- Farooqi, I. Sadaf (author)
- University Of Cambridge
-
- Ralser, Markus (author)
- The Francis Crick Institute,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin
-
show less...
-
(creator_code:org_t)
- 2023-01-20
- 2023
- English.
-
In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 108:8, s. 2087-2098
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://research.cha...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Context: Humans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses. Objective: Endocrine parameters and the metabolome of human plasma are rapidly responding to acute nutritional interventions such as caloric restriction or a glucose challenge. It is less well understood whether the plasma proteome would be equally dynamic, and whether it could be a source of corresponding biomarkers. Methods: We used high-throughput mass spectrometry to determine changes in the plasma proteome of i) 10 healthy, young, male individuals in response to 2 days of acute caloric restriction followed by refeeding; ii) 200 individuals of the Ely epidemiological study before and after a glucose tolerance test at 4 time points (0, 30, 60, 120 minutes); and iii) 200 random individuals from the Generation Scotland study. We compared the proteomic changes detected with metabolome data and endocrine parameters. Results: Both caloric restriction and the glucose challenge substantially impacted the plasma proteome. Proteins responded across individuals or in an individual-specific manner. We identified nutrient-responsive plasma proteins that correlate with changes in the metabolome, as well as with endocrine parameters. In particular, our study highlights the role of apolipoprotein C1 (APOC1), a small, understudied apolipoprotein that was affected by caloric restriction and dominated the response to glucose consumption and differed in abundance between individuals with and without type 2 diabetes. Conclusion: Our study identifies APOC1 as a dominant nutritional responder in humans and highlights the interdependency of acute nutritional response proteins and the endocrine system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- oral glucose tolerance test
- type 2 diabetes
- caloric restriction
- plasma proteomics
- APOC1
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Vernardis,
-
Demichev, Vadim
-
Lemke, Oliver
-
Gruening, Nana-M ...
-
Messner, Christo ...
-
White, Matt
-
show more...
-
Pietzner, Maik
-
Peluso, Alina
-
Collet, Tinh-Hai
-
Henning, Elana
-
Gille, Christoph
-
Campbell, Archie
-
Hayward, Carolin ...
-
Porteous, David ...
-
Marioni, Riccard ...
-
Muelleder, Micha ...
-
Zelezniak, Aleks ...
-
Langenberg, Clau ...
-
Farooqi, I. Sada ...
-
Ralser, Markus
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Chalmers University of Technology