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Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
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- Chen, Yun, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
- Daviet, L. (author)
- Schalk, M. (author)
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- Elsevier BV, 2013
- 2013
- English.
- In: Metabolic Engineering. - : Elsevier BV. - 1096-7176 .- 1096-7184. ; 15:1, s. 48-54
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of alpha-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Acetyl-CoA
- Saccharomyces cerevisiae
- saccharomyces-cerevisiae
- pyruvate-decarboxylase
- expression
- Cell factory
- growth-rate
- precursor
- synthetase
- alpha-Santalene
- sequence
- glucose
- transcription
- fermentation
Publication and Content Type
- art (subject category)
- ref (subject category)
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