onr:"swepub:oai:slubar.slu.se:26493"
Search: onr:"swepub:oai:slubar.slu.se:26493" > In silico analysis ...
- 1 of 1
- Previous record
- Next record
- To hitlist
In silico analysis of the dog genome identifies Canine Endogenous Retroviruses (CfERVs)
-
- Ekerljung, Marie (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
-
- Bongcam Rudloff, Erik (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
-
- Andersson, Göran (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
- (creator_code:org_t)
- 2009
- 2009
- English.
- In: Retrovirology. - 1742-4690. ; 6
- Conference paper (peer-reviewed)
Abstract
Subject headings
Close
- A whole dog genome analysis was perfomed using RetroTector© to identify and define the complexity of canine endogenous retroviruses (CfERV). Results show that all dog chromosomes contain CfERV integrations. Furthermore, the integration pattern was shown to be uneven with some regions essentially devoid of integrations and other regions having large amounts of CfERV integrations. The dog may well have been effective in protecting its genome from integrations of most types of endogenous retroviruses. Compared to mouse, chimpanzee and human, dog has substantially lower amounts of ERVs. We identified a total of 416 ERVs, which is only approximately a fifth of the amount of HERVs found in the human genome. Phylogenetic analysis showed that the vast majority of CfERVs cluster with the gammaretrovirus genus (n = 318). The second most common group was the beta-retroviruses (n = 27). This pattern is similar in other vertebrates. In addition, three spuma-like and four gypsy-like CfERVs were identified. The latter group is rare in vertebrate genomes. Moreover, we identified a group of 55 CfERVs with mixed phylogenetic relationship to any known retroviral genera. The integration pattern of CfERVs was analyzed in relation to genes in their vicinity and a substantial fraction of CfERV was found within annotated genes and within 100 kb from annotated dog genes. Interestingly, a group of recently integrated CfERVs with similarity to HERV-Fc1 was found. Several of them had all or nearly all major reading frames open, a sign of functionality. Therefore, some of these CfERVs may have potential for active retrotransposition and thus actively contribute to the plasticity of canine genomes. The differential distribution and amounts of ERVs in the dog genome compared to genomes in the primate and rodent clades suggest species-specific mechanisms of purging different classes of ERVs
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
Publication and Content Type
- ref (subject category)
- kon (subject category)
Find in a library
- Retrovirology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ekerljung, Marie
- Bongcam Rudloff, ...
- Andersson, Göran
- About the subject
-
- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
- and Veterinary Scien ...
-
- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
- and Animal and Dairy ...
- Articles in the publication
- Retrovirology
- By the university
- Swedish University of Agricultural Sciences
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
