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- Frykberg, LarsSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology (author)
Antiphagocytic Function of an IgG Glycosyl Hydrolase from Streptococcus equi subsp equi and Its Use as a Vaccine Component
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- 2012
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- LIBRIS-ID:oai:slubar.slu.se:41501
- https://res.slu.se/id/publ/41501URI
- https://doi.org/10.1128/IAI.06083-11DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:124984284URI
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- Language:English
- Summary in:English
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Notes
- Endo Se from Streptococcus equi subsp. equi is an enzyme hydrolyzing glycosyl groups on IgG, analogous to EndoS from Streptococcus pyogenes. We here show that the activity of EndoSe leads to an antiphagocytic function and may thus be a contributory factor to immune evasion of S. equi. Despite the damaging effect that EndoSe has on IgG, antibodies against EndoSe can neutralize its function. Antibodies against EndoSe restored the opsonic activity of specific opsonizing antibodies. Mice infected with either S. equi subsp. equi or subsp. zooepidemicus or S. pyogenes could be protected by vaccination with EndoSe. It is speculated that EndoSe could be a suitable vaccine candidate against streptococcal infections.
Subject headings and genre
- LANTBRUKSVETENSKAPER Veterinärmedicin Annan veterinärmedicin hsv//swe
- AGRICULTURAL SCIENCES Veterinary Science Other Veterinary Science hsv//eng
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- NATURVETENSKAP Biologi Mikrobiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Microbiology hsv//eng
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- Guss, BengtSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology(Swepub:slu)49233 (author)
- Flock, MKarolinska Institutet (author)
- Skold, MKarolinska Institutet (author)
- Flock, JIKarolinska Institutet (author)
- Sveriges lantbruksuniversitetInstitutionen för mikrobiologi (creator_code:org_t)
- Sveriges lantbruksuniversitet
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- In:Infection and Immunity80, s. 2914-29190019-95671098-5522
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