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Träfflista för sökning "WFRF:(Galimberti V) "

Search: WFRF:(Galimberti V)

  • Result 51-60 of 74
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  • Houshmand, M, et al. (author)
  • Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome
  • 2021
  • In: Cancers. - : MDPI AG. - 2072-6694. ; 13:6
  • Journal article (peer-reviewed)abstract
    • CML is a hematopoietic stem-cell disorder emanating from breakpoint cluster region/Abelson murine leukemia 1 (BCR/ABL) translocation. Introduction of different TKIs revolutionized treatment outcome in CML patients, but CML LSCs seem insensitive to TKIs and are detectable in newly diagnosed and resistant CML patients and in patients who discontinued therapy. It has been reported that CML LSCs aberrantly express some CD markers such as CD26 that can be used for the diagnosis and for targeting. In this study, we confirmed the presence of CD26+ CML LSCs in newly diagnosed and resistant CML patients. To selectively target CML LSCs/progenitor cells that express CD26 and to spare normal HSCs/progenitor cells, we designed a venetoclax-loaded immunoliposome (IL-VX). Our results showed that by using this system we could selectively target CD26+ cells while sparing CD26− cells. The efficiency of venetoclax in targeting CML LSCs has been reported and our system demonstrated a higher potency in cell death induction in comparison to free venetoclax. Meanwhile, treatment of patient samples with IL-VX significantly reduced CD26+ cells in both stem cells and progenitor cells population. In conclusion, this approach showed that selective elimination of CD26+ CML LSCs/progenitor cells can be obtained in vitro, which might allow in vivo reduction of side effects and attainment of treatment-free, long-lasting remission in CML patients.
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  • Kundrat, J., et al. (author)
  • GNPy : Lessons Learned and Future Plans [Invited]
  • 2022
  • In: 2022 European Conference on Optical Communication, ECOC 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781957171159
  • Conference paper (peer-reviewed)abstract
    • We discuss the history, past challenges and future plans of GNPy, an open source project for simulating physical impairments in contemporary DWDM network. The paper describes the unique interaction among network operators, equipment vendors, and standard bodies, as well as challenges in implementing the digital twin of an optical network.
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  • Kundrat, J., et al. (author)
  • GNPy YANG : Open APIs for End-to-End Service Provisioning in Optical Networks
  • 2021
  • In: 2021 Optical Fiber Communications Conference and Exhibition, OFC 2021 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781943580866
  • Conference paper (peer-reviewed)abstract
    • We demonstrate end-to-end service provisioning in a fully disaggregated optical network using open software interfaces. The GNPy quality-of-transmission estimator is extended with a YANG-based API. The YANG modeling work builds on the IETF standard schemas, and describes multiple layers of the network at once. 
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  • Result 51-60 of 74

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