| 81. |
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| 82. |
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| 83. |
- Bryois, J, et al.
(author)
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Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia
- 2018
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 3121-
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Journal article (peer-reviewed)abstract
- Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants.
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| 84. |
- Caretta, Martina Angela, et al.
(author)
-
Water
- 2022
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In: Climate Change 2022: Impacts, Adaptation and Vulnerability : Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change - Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change.
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Book chapter (other academic/artistic)
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| 85. |
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| 86. |
- Chattopadhyay, G., et al.
(author)
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Decision on economical rail grinding interval for controlling rolling contact fatigue
- 2005
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In: International Transactions in Operational Research. - : Wiley. - 0969-6016 .- 1475-3995. ; 12:6, s. 545-558
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Journal article (peer-reviewed)abstract
- Rail players around the world have been increasing axle loads to improve the productivity of freight and heavy haul operations. This has increased the risk of surface cracks at curves because of rolling contact fatigue. Rail grinding has been considered an effective process for controlling these cracks and reducing risks of rail breaks. The complexity of deciding the optimal rail grinding intervals for improving the reliability and safety of rails is because of insufficient understanding of the various factors involved in the crack initiation and propagation process. This paper focuses on identifying the factors influencing rail degradation, developing models for rail failures and analyzing the costs of various grinding intervals for economic decision making. Various costs involved in rail maintenance, such as rail grinding, downtime, inspection, rail failures and derailment, and replacement of worn-out rails, are incorporated into the total cost model developed in this paper. Field data from the rail industry have been used for illustration.
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| 87. |
- Chattopadhyay, G., et al.
(author)
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Modelling and analysis of rail maintenance cost
- 2007
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In: International Journal of Production Economics. - : Elsevier BV. - 0925-5273 .- 1873-7579. ; 105:2, s. 475-482
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Journal article (peer-reviewed)abstract
- Lubrication at wheel flange and rails on sharp curves is considered as an effective solution for reducing wear loss of material from effective cross-section of rail and wheels. Rail administrations around the world have been increasing axle loads and traffic densities in rail networks. This has led to traffic initiated wear, fatigue initiated surface cracks and rail breaks. Limited research has been carried out on the overall impact of combining lubrication strategies and rail grinding. This paper presents a model for lubrication strategy and rail-grinding interval to reduce wear and rolling contact fatigue (RCF). Data from rail industry is collected and used for numerical illustration.
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| 88. |
- Chattopadhyay, G., et al.
(author)
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Rail-wheel lubrication : A conceptual decision model
- 2005
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In: International Conference on Operations Research Applications in Infrastructure Development in conjunction with the 2005 Annual Convention of Operational Research Society of India (ICORAID-2005-ORSI).
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Conference paper (peer-reviewed)
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| 89. |
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| 90. |
- Chndrasekhararao, A. V., et al.
(author)
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Phytoplankton response to the contrasting physical regimes in the eastern Arabian Sea during north east monsoon
- 2018
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In: Journal of Marine Systems. - : Elsevier BV. - 0924-7963 .- 1879-1573.
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Journal article (peer-reviewed)abstract
- Phytoplankton abundance and composition in two contrasting physical regimes - convective mixing in the northeastern Arabian Sea (NEAS) and Arabian Sea mini warm pool (ASMWP) in the southeastern Arabian Sea(SEAS) - were investigated during the northeast monsoon (NEM) of 2015 and 2017. Observations in 2015 were carried out late during the season, and only one station in the north (at 21°N latitude) fell within the zone of convective mixing where microplankton was dominated by diatoms. In 2017, convective mixing occurred even at 16°N latitude, but the microplankton contribution was low, presumably due to low Si/N ratios. Within the convective mixing regime of the NEAS, chlorophyll (Chl) concentrations were higher in 2015 (maximum1080 ng L-1; average 493 ng L-1) than in 2017 (maximum 673 ng L-1; average 263 ng L-1). In contrast, picophytoplankton was dominant in the ASMWP of the SEAS with peak abundance associated with the subsurface chlorophyll maximum. A warm core eddy was present in 2015 in the SEAS where four times higherProchlorococcus counts were found within the core of the eddy than at its periphery. This study provides the first description of the phytoplankton community in the ASMWP. Our results clearly demonstrate phytoplankton response to the contrasting physical conditions, highlighting the role of biophysical coupling in the productivity of the Arabian Sea
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