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101.	Winkler, TW, et al. (author) Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals 2022 In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 580- Journal article (peer-reviewed)abstract Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
102.	Xu, WH, et al. (author) Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on Second Near-Infrared (NIR-II) Aggregation-Induced Emission Luminogens (AIEgens) 2020 In: ACS MATERIALS LETTERS. - : American Chemical Society (ACS). - 2639-4979. ; 2:8, s. 1033-1040 Journal article (other academic/artistic)
103.	Yu, WH, et al. (author) Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease 2005 In: The Journal of cell biology. - : Rockefeller University Press. - 0021-9525 .- 1540-8140. ; 171:1, s. 87-98 Journal article (peer-reviewed)abstract Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In this study, we show that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β-amyloidosis. Subsequently, autophagosomes and late autophagic vacuoles (AVs) accumulate markedly in dystrophic dendrites, implying an impaired maturation of AVs to lysosomes. Immunolabeling identifies AVs in the brain as a major reservoir of intracellular Aβ. Purified AVs contain APP and β-cleaved APP and are highly enriched in PS1, nicastrin, and PS-dependent γ-secretase activity. Inducing or inhibiting macroautophagy in neuronal and nonneuronal cells by modulating mammalian target of rapamycin kinase elicits parallel changes in AV proliferation and Aβ production. Our results, therefore, link β-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD.
104.	Zhou, B, et al. (author) Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants 2017 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 389:10064, s. 37-55 Journal article (peer-reviewed)
105.	Zhou, Bin, et al. (author) Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants 2021 In: Lancet (London, England). - : Elsevier. - 1474-547X .- 0140-6736. ; 398:10304, s. 957-980 Journal article (peer-reviewed)

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Result 101-105 of 105

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Type of publication: journal article (96); research review (1)

Type of content: peer-reviewed (89); other academic/artistic (8)

Author/Editor: Lee, J. (21); Metspalu, A (20); Mahajan, A. (19); Wong, TY (19); Joshi, P. (19); Kumar, S (18); show more...; Jonas, JB (18); Gudnason, V (18); He, J (18); Salomaa, V (18); Wang, YX (18); Peters, A (17); Kumar, A. (17); Pellino, G (17); Ikram, MA (17); Elliott, P (17); Lehtimaki, T. (17); Bata, I (17); Sy, RG (17); Campain, N (16); Davies, RJ (16); Diaz, A. (16); Zheng, W. (16); Cheng, CY (16); Taylor, A (16); Boehnke, M (16); Davies, M. (15); Kim, H. (15); Liu, J. (15); Poggioli, G (15); Evans, A. (15); Kim, J. (15); Khan, A. (15); Vohra, R (15); Sabanayagam, C (15); Guo, Y (14); Das, S. (14); Santos, R. (14); Yang, J. (14); Lin, X. (14); Smart, NJ (14); Ahmed, A (14); Ribeiro, R (14); Hall, J (14); Vollenweider, P. (14); Thomas, M (14); Dorobantu, M (14); Lind, L (14); Gu, DF (14); Pecin, I (14); show less...

University: Karolinska Institutet (95); Lund University (25); Uppsala University (24); Umeå University (17); University of Gothenburg (14); Royal Institute of Technology (7); show more...; University of Skövde (5); Högskolan Dalarna (4); Linköping University (3); Luleå University of Technology (1); Stockholm University (1); Örebro University (1); Stockholm School of Economics (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (105)

Research subject (UKÄ/SCB): Medical and Health Sciences (51); Natural sciences (10); Social Sciences (1)

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