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1.	Lorenzini, Luigi, et al. (author) Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals 2024 In: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279. Journal article (peer-reviewed)abstract INTRODUCTION: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. METHODS: We computed pathway-specific genetic risk scores (GRSs) in non-demented individuals and investigated how AD risk variants predict cerebrospinal fluid (CSF) and imaging biomarkers reflecting AD pathology, cardiovascular, white matter integrity, and brain connectivity. RESULTS: CSF amyloidbeta and phosphorylated tau were related to most GRSs. Inflammatory pathways were associated with cerebrovascular disease, whereas quantitative measures of white matter lesion and microstructure integrity were predicted by clearance and migration pathways. Functional connectivity alterations were related to genetic variants involved in signal transduction and synaptic communication. DISCUSSION: This study reveals distinct genetic risk profiles in association with specific pathophysiological aspects in predementia stages of AD, unraveling the biological substrates of the heterogeneity of AD-associated endophenotypes and promoting a step forward in disease understanding and development of personalized therapies. Highlights Polygenic risk for Alzheimer's disease encompasses six biological pathways that can be quantified with pathway-specific genetic risk scores, and differentially relate to cerebrospinal fluid and imaging biomarkers. Inflammatory pathways are mostly related to cerebrovascular burden. White matter health is associated with pathways of clearance and membrane integrity, whereas functional connectivity measures are related to signal transduction and synaptic communication pathways.
2.	2019 Journal article (peer-reviewed)
3.	Aad, G., et al. (author) ATLAS measurements of the properties of jets for boosted particle searches 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:7 Journal article (peer-reviewed)
4.	Aad, G., et al. (author) Combined search for the Standard Model Higgs boson in pp collisions at root s=7 TeV with the ATLAS detector 2012 In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 86:3 Journal article (peer-reviewed)
5.	Aad, G., et al. (author) Drift Time Measurement in the ATLAS Liquid Argon Electromagnetic Calorimeter using Cosmic Muons 2010 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 755-785 Journal article (peer-reviewed)
6.	Aad, G., et al. (author) Evidence for the associated production of a W boson and a top quark in ATLAS at root s=7 TeV 2012 Journal article (peer-reviewed)
7.	Aad, G., et al. (author) Measurement of event shapes at large momentum transfer with the ATLAS detector in pp collisions at root s=7 TeV 2012 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 72:11 Journal article (peer-reviewed)
8.	Aad, G., et al. (author) Measurement of the W boson polarization in top quark decays with the ATLAS detector 2012 In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6 Journal article (peer-reviewed)
9.	Aad, G., et al. (author) Readiness of the ATLAS liquid argon calorimeter for LHC collisions 2010 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 723-753 Journal article (peer-reviewed)
10.	Aad, G., et al. (author) Search for a fermiophobic Higgs boson in the diphoton decay channel with the ATLAS detector 2012 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 72:9 Journal article (peer-reviewed)

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Type of publication: journal article (161); research review (7); conference paper (3); book chapter (1)

Type of content: peer-reviewed (162); other academic/artistic (10)

Author/Editor: Aad, G (52); Abbott, B. (52); Abdinov, O (52); Abi, B. (52); Abramowicz, H. (52); Adams, D. L. (52); show more...; Adelman, J. (52); Adye, T. (52); Aielli, G. (52); Akimoto, G. (52); Akimov, A. V. (52); Albrand, S. (52); Aleksa, M. (52); Aleksandrov, I. N. (52); Alexander, G. (52); Alexandre, G. (52); Alexopoulos, T. (52); Alhroob, M. (52); Alimonti, G. (52); Allport, P. P. (52); Almond, J. (52); Amako, K. (52); Amelung, C. (52); Amram, N. (52); Anastopoulos, C. (52); Anderson, K. J. (52); Angerami, A. (52); Anghinolfi, F. (52); Antonaki, A. (52); Antonelli, M. (52); Arabidze, G. (52); Aracena, I. (52); Arai, Y. (52); Arguin, J-F. (52); Arnaez, O. (52); Asai, S. (52); Asquith, L. (52); Assamagan, K. (52); Avolio, G. (52); Azuma, Y. (52); Bachacou, H. (52); Bachas, K. (52); Backes, M. (52); Baines, J. T. (52); Baker, O. K. (52); Banas, E. (52); Barbero, M. (52); Barillari, T. (52); Barisonzi, M. (52); Barklow, T. (52); show less...

University: Uppsala University (160); Lund University (63); Stockholm University (53); Royal Institute of Technology (52); University of Gothenburg (7); Karolinska Institutet (5); show more...; Linköping University (4); Blekinge Institute of Technology (4); Luleå University of Technology (3); Umeå University (1); Halmstad University (1); Chalmers University of Technology (1); RISE (1); Högskolan Dalarna (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (172)

Research subject (UKÄ/SCB): Medical and Health Sciences (105); Natural sciences (56); Engineering and Technology (6); Agricultural Sciences (2); Social Sciences (2)

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