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- Sabatelli, L., et al.
(author)
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Burden of hospitalizations and outpatient visits associated with moderate and severe acute graft-versus-host disease in Finland and Sweden: a real-world data study
- 2022
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In: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339. ; 30, s. 5125-5135
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Journal article (peer-reviewed)abstract
- Purpose: The aim of this study was to describe patient characteristics and quantify hospital stays and outpatient visits (H&OV) following diagnosis with moderate-to-severe acute graft-versus-host disease (aGVHD) in Finland and Sweden. Methods: A retrospective chart audit collected data from patient medical records of 3 specialized centers performing allogeneic hematopoietic stem cell transplantation (HSCT; Finland, n = 2; Sweden, n = 1). Eligible patients received allogeneic HSCT (January 1, 2016–June 30, 2017) from any donor source, were diagnosed with grade II–IV aGVHD (MAGIC or modified Glucksberg criteria) at any time from transplantation to 12months before data collection, and were ≥ 18years old at diagnosis.Criteria for comparing patients graded with modified Glucksberg and MAGIC severity scales were defined. Results: Fifty-five patients (Finland, n = 45; Sweden, n = 10) were included. Myeloablative conditioning was the most common conditioning regimen (81.8%); immunosuppression regimens were based on combinations of methotrexate (96.4%), in vivo T-cell depletion (80.0%), cyclosporine (63.6%), mycophenolate (40.0%), and tacrolimus (34.5%). Sixteen patients (29.1%) developed grade III/IV aGVHD; skin was the most common organ involved (80.0%). Most patients required ≥ 1 hospital stay (89.1%; median of 2 hospitalizations per patient); 7 patients (14.3%) required admission to an intensive care unit. Median hospitalization duration from HSCT to discharge was 26days. Most patients also required outpatient or emergency department visits (90.9%). Subgroup analyses showed longer hospital stays for patients receiving multiple treatment lines; no clear differences in H&OV were observed between prophylactic regimens. Conclusion: Based on this retrospective study, moderate-to-severe aGVHD is associated with considerable healthcare resource utilization in Finland and Sweden, particularly in patients who received multiple lines of therapy. © 2022, The Author(s).
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- Abdallah, N., et al.
(author)
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Hilbert Functions and Jordan Type of Perazzo Artinian Algebras
- 2024
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In: Springer INdAM Series. - : Springer-Verlag Italia s.r.l.. ; , s. 59-80
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Book chapter (other academic/artistic)abstract
- We study Hilbert functions, Lefschetz properties, and Jordan type of Artinian Gorenstein algebras associated to Perazzo hypersurfaces in projective space. The main focus lies on Perazzo threefolds, for which we prove that the Hilbert functions are always unimodal. Further we prove that the Hilbert function determines whether the algebra is weak Lefschetz, and we characterize those Hilbert functions for which the weak Lefschetz property holds. By example, we verify that the Hilbert functions of Perazzo fourfolds are not always unimodal. In the particular case of Perazzo threefolds with the smallest possible Hilbert function, we give a description of the possible Jordan types for multiplication by any linear form.
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- Andersson, LI, et al.
(author)
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Towards molecular-imprint based SPE of local anaesthetics
- 2002
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In: Chromatographia. - 0009-5893. ; 55, s. 65-69
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Journal article (peer-reviewed)abstract
- The use of imprinted polymers for selective solid-phase extraction of local anaesthetics from human plasma was investigated. Methacrylic acid-ethylene glycol dimethacrylate based MIPs were developed by the alternative template approach using a structural analogue, pentycaine, as the template. The influence of the type and concentration of detergent in the buffer on selective and non-specific binding was investigated. Tween 20, Triton X-100 and Brij 35 were found to eliminate non-specific adsorption and leave selective imprint-onalyte binding essentially unaffected. Efficient pre-concert ration of ropivacaine and bupivacaine from plasma samples, both off-line prior to GC and in-line with LC-MS-MS, was demonstrated.
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- Cooper, S. M., et al.
(author)
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The Weak Lefschetz Property of Whiskered Graphs
- 2024
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In: Springer INdAM Series. - : Springer-Verlag Italia s.r.l.. ; , s. 97-110
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Book chapter (other academic/artistic)abstract
- We consider Artinian level algebras arising from the whiskering of a graph. Employing a result by Dao-Nair we show that multiplication by a general linear form has maximal rank in degrees 1 and n-1 when the characteristic is not two, where n is the number of vertices in the graph. Moreover, the multiplication is injective in degrees
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- Einarsdottir, Sigrun, et al.
(author)
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Vaccination against tick-borne encephalitis (TBE) after autologous and allogeneic stem cell transplantation
- 2021
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In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 39:7, s. 1035-1038
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Journal article (peer-reviewed)abstract
- Introduction: Our aim was to assess response and side effects of 4 doses of TBE vaccine to patients (pts) after allo- and autologous stem cell transplantation (SCT). PATIENTS: Included were 104 pts with leukaemia, myeloma and lymphoma, median age 61 yrs. METHODS: Vaccine (FSME-Immun (R)) was given at 9, 10, 12, and 21 months post-transplant. Serum samples were obtained before and after vaccinations. Healthy controls (n = 27) received 3 vaccinations. Assessments of TBE specific IgG antibodies were performed by Enzygnost anti-TBE ELISA test (Siemens, Sweden). Results: Antibody levels (>12 U/mL; "seropositivity") were seen in 77% and 80% of pts after allo- and autoSCT; IgG levels; 89 vs 94 U/mL. Ongoing chronic GvHD and immunosuppression (n = 29) was associated with sero-negativity in the last sample (p = 0.007). All controls (n = 27) developed protective antibody levels. Conclusions: TBE vaccination was safe, and 4 doses starting 9 months post-SCT, induced seropositivity in a vast majority of pts. (C) 2021 Elsevier Ltd. All rights reserved.
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- Härkönen, M., et al.
(author)
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Syzygies, constant rank, and beyond
- 2024
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In: Journal of symbolic computation. - : Academic Press. - 0747-7171 .- 1095-855X. ; 123
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Journal article (peer-reviewed)abstract
- We study linear PDE with constant coefficients. The constant rank condition on a system of linear PDEs with constant coefficients is often used in the theory of compensated compactness. While this is a purely linear algebraic condition, the nonlinear algebra concept of primary decomposition is another important tool for studying such system of PDEs. In this paper we investigate the connection between these two concepts. From the nonlinear analysis point of view, we make some progress in the study of weak lower semicontinuity of integral functionals defined on sequences of PDE constrained fields, when the PDEs do not have constant rank.
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