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Träfflista för sökning "WFRF:(Sunyer Jordi) ;srt2:(2015-2019)"

Search: WFRF:(Sunyer Jordi) > (2015-2019)

  • Result 21-22 of 22
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21.
  • Tischer, Christina, et al. (author)
  • Predictors of microbial agents in dust and respiratory health in the Ecrhs
  • 2015
  • In: BMC Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 15
  • Journal article (peer-reviewed)abstract
    • Background: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. Methods: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. Results: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95% CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.
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22.
  • van der Valk, Ralf J P, et al. (author)
  • A novel common variant in DCST2 is associated with length in early life and height in adulthood.
  • 2015
  • In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 24:4, s. 1155-68
  • Journal article (peer-reviewed)abstract
    • Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
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  • Result 21-22 of 22
Type of publication
journal article (22)
Type of content
peer-reviewed (21)
other academic/artistic (1)
Author/Editor
Sunyer, Jordi (22)
Heinrich, Joachim (13)
Jarvis, Deborah (7)
Carsin, Anne-Elie (7)
Siroux, Valérie (7)
Janson, Christer (6)
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Leynaert, Benedicte (6)
Pin, Isabelle (6)
Marcon, Alessandro (6)
Keidel, Dirk (6)
Probst-Hensch, Nicol ... (6)
Jacquemin, Benedicte (6)
Bono, Roberto (6)
Brunekreef, Bert (6)
Forsberg, Bertil (5)
Hardy, Rebecca (5)
Villani, Simona (5)
de Hoogh, Kees (5)
Künzli, Nino (5)
Jacobsson, Bo, 1960 (4)
Svanes, Cecilie (4)
Cooper, Cyrus (4)
Tsai, Ming-Yi (4)
de Nazelle, Audrey (4)
Schindler, Christian (4)
Peeters, Petra H (3)
Overvad, Kim (3)
Kaaks, Rudolf (3)
Boeing, Heiner (3)
Trichopoulou, Antoni ... (3)
Norat, Teresa (3)
Riboli, Elio (3)
Diaz, Alejandro (3)
Joffres, Michel (3)
McKee, Martin (3)
Magnus, Per (3)
Salomaa, Veikko (3)
Lundqvist, Annamari (3)
Giwercman, Aleksande ... (3)
Wade, Alisha N. (3)
Raitakari, Olli T (3)
Accordini, Simone (3)
Koppelman, Gerard H. (3)
Adam, Martin (3)
Sanchez, Margaux (3)
Nadif, Rachel (3)
Nieuwenhuijsen, Mark ... (3)
Melbye, Mads (3)
Brenner, Hermann (3)
Claessens, Frank (3)
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University
Umeå University (9)
Uppsala University (8)
University of Gothenburg (6)
Lund University (4)
Karolinska Institutet (4)
Luleå University of Technology (2)
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Mid Sweden University (2)
Örebro University (1)
Högskolan Dalarna (1)
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Language
English (22)
Research subject (UKÄ/SCB)
Medical and Health Sciences (21)
Social Sciences (1)

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