SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"22069191"
 

Sökning: onr:"22069191" > The genome of Spiro...

The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments

Xu, Feifei (författare)
Jerlström-Hultqvist, Jon (författare)
Einarsson, Elin (författare)
visa fler...
Astvaldsson, Asgeir (författare)
Svärd, Staffan G (författare)
Andersson, Jan O 1971- (författare)
visa färre...
 (utgivare)
 (utgivare)
visa fler...
 (utgivare)
 (utgivare)
 (medarbetare)
visa färre...
2014
2014
Engelska.
Ingår i: PLoS Genetics. - 1553-7390. ; 10:2, e1004053
  • swepub:Mat__t
Abstract Ämnesord
Stäng  
  • Spironucleus salmonicida causes systemic infections in salmonid fish. It belongs to the group diplomonads, binucleated heterotrophic flagellates adapted to micro-aerobic environments. Recently we identified energy-producing hydrogenosomes in S. salmonicida. Here we present a genome analysis of the fish parasite with a focus on the comparison to the more studied diplomonad Giardia intestinalis. We annotated 8067 protein coding genes in the ∼12.9 Mbp S. salmonicida genome. Unlike G. intestinalis, promoter-like motifs were found upstream of genes which are correlated with gene expression, suggesting a more elaborate transcriptional regulation. S. salmonicida can utilise more carbohydrates as energy sources, has an extended amino acid and sulfur metabolism, and more enzymes involved in scavenging of reactive oxygen species compared to G. intestinalis. Both genomes have large families of cysteine-rich membrane proteins. A cluster analysis indicated large divergence of these families in the two diplomonads. Nevertheless, one of S. salmonicida cysteine-rich proteins was localised to the plasma membrane similar to G. intestinalis variant-surface proteins. We identified S. salmonicida homologs to cyst wall proteins and showed that one of these is functional when expressed in Giardia. This suggests that the fish parasite is transmitted as a cyst between hosts. The extended metabolic repertoire and more extensive gene regulation compared to G. intestinalis suggest that the fish parasite is more adapted to cope with environmental fluctuations. Our genome analyses indicate that S. salmonicida is a well-adapted pathogen that can colonize different sites in the host.

Ämnesord

Natural Sciences  (hsv)
Biological Sciences  (hsv)
Microbiology  (hsv)
Naturvetenskap  (hsv)
Biologiska vetenskaper  (hsv)
Mikrobiologi  (hsv)
Natural Sciences  (hsv)
Biological Sciences  (hsv)
Genetics  (hsv)
Naturvetenskap  (hsv)
Biologiska vetenskaper  (hsv)
Genetik  (hsv)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy