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Efficient mapping o...
Efficient mapping of mendelian traits in dogs through genome-wide association
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Karlsson, Elinor K. (author)
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Baranowska, Izabella (author)
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Wade, Claire M. (author)
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- Salmon Hillbertz, Nicolette H. C. (author)
- Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
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Zody, Michael C. (author)
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Anderson, Nathan (author)
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Biagi, Tara M. (author)
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Patterson, Nick (author)
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- Pielberg, Gerli Rosengren (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Kulbokas, Edward J. (author)
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Comstock, Kenine E. (author)
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Keller, Evan T. (author)
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Mesirov, Jill P. (author)
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von Euler, Henrik (author)
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- Kämpe, Olle (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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Hedhammar, Åke (author)
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Lander, Eric S. (author)
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Andersson, Göran (author)
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- Andersson, Leif (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2007-09-30
- 2007
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:11, s. 1321-1328
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with |[sim]|27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only |[sim]|20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting (S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of <1 Mb. Fine-mapping of the S locus in two breeds refines the localization to a region of |[sim]|100 kb contained within the pigmentation-related gene MITF. Complete sequencing of the white and solid haplotypes identifies candidate regulatory mutations in the melanocyte-specific promoter of MITF. Our results show that genome-wide association mapping within dog breeds, followed by fine-mapping across multiple breeds, will be highly efficient and generally applicable to trait mapping, providing insights into canine and human health.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Karlsson, Elinor ...
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Baranowska, Izab ...
-
Wade, Claire M.
-
Salmon Hillbertz ...
-
Zody, Michael C.
-
Anderson, Nathan
-
show more...
-
Biagi, Tara M.
-
Patterson, Nick
-
Pielberg, Gerli ...
-
Kulbokas, Edward ...
-
Comstock, Kenine ...
-
Keller, Evan T.
-
Mesirov, Jill P.
-
von Euler, Henri ...
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Kämpe, Olle
-
Hedhammar, Åke
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Lander, Eric S.
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Andersson, Göran
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Andersson, Leif
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Lindblad-Toh, Ke ...
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show less...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University