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Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease
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- Vedin, Ola (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Hagström, Emil (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Östlund, Ollie (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Avezum, Alvaro (author)
- Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
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- Budaj, Andrzej (author)
- Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland.
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- Flather, Marcus D. (author)
- Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.;Norfolk & Norwich Univ Hosp, Norwich Med Sch, Norwich, Norfolk, England.
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- Harrington, Robert A. (author)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
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- Koenig, Wolfgang (author)
- Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, Ulm, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK German Ctr Cardiovascular Res, Partner Site Munich Heart Alliance, Munich, Germany.
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- Soffer, Joseph (author)
- GlaxoSmithKline, Metab Pathways & Cardiovasc Therapeut Area, King Of Prussia, PA USA.
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Steg, Philippe Gabriel (author)
- INSERM Unite 1148, Paris, France.;Dept Hosp Univ FIRE, Hop Bichat, AP HP, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.;NHLI Imperial Coll, Royal Brompton Hosp, ICMS, London, England.
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- Stewart, Ralph A. H. (author)
- Univ Auckland, Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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White, Harvey D. (author)
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- Held, Claes, 1956- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 245, s. 271-276
- Related links:
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https://ueaeprints.u...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background:Underlying mechanisms behind the hypothesized relationship between periodontal disease (PD) and coronary heart disease (CHD) have been insufficiently explored. We evaluated associations between self-reported tooth loss-a marker of PD- and prognostic biomarkers in 15,456 (97%) patients with stable CHD in the global STABILITY trial.Methods and results:Baseline blood samples were obtained and patients reported their number of teeth according to the following tooth loss levels: "26-32 (All)" [lowest level], "20-25", "15-19", "1-14", and "No Teeth" [highest level]. Linear and Cox regression models assessed associations between tooth loss levels and biomarker levels, and the relationship between tooth loss levels and outcomes, respectively.After multivariable adjustment, the relative biomarker increase between the highest and the lowest tooth loss level was: high-sensitivity C-reactive protein 1.21 (95% confidence interval, 1.14-1.29), interleukin 6 1.14 (1.10-1.18), lipoprotein-associated phospholipase A(2) activity 1.05 (1.03-1.06), growth differentiation factor 15 1.11 (1.08-1.14), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) 1.18 (1.11-1.25). No association was detected for high-sensitivity troponin T 1.02 (0.98-1.05). Some attenuation of the relationship between tooth loss and outcomes resulted from the addition of biomarkers to the multivariable analysis, of which NT-proBNP had the biggest impact.Conclusions:A graded and independent association between tooth loss and several prognostic biomarkers was observed, suggesting that tooth loss and its underlying mechanisms may be involved in multiple pathophysiological pathways also implicated in the development and prognosis of CHD. The association between tooth loss and cardiovascular death and stroke persisted despite comprehensive adjustment including prognostic biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Tooth loss
- Periodontal disease
- Stable coronary heart disease
- Biomarkers
- Risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vedin, Ola
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Hagström, Emil
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Östlund, Ollie
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Avezum, Alvaro
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Budaj, Andrzej
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Flather, Marcus ...
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Harrington, Robe ...
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Koenig, Wolfgang
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Soffer, Joseph
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Siegbahn, Agneta ...
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Steg, Philippe G ...
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Stewart, Ralph A ...
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Wallentin, Lars, ...
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White, Harvey D.
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Held, Claes, 195 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Uppsala University