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Longitudinal Struct...
Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group.
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- Abé, Christoph (author)
- Karolinska Institutet
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Ching, Christopher R K (author)
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Liberg, Benny (author)
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Lebedev, Alexander V (author)
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- Agartz, Ingrid (author)
- Karolinska Institutet
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Akudjedu, Theophilus N (author)
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Alda, Martin (author)
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Alnæs, Dag (author)
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Alonso-Lana, Silvia (author)
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Benedetti, Francesco (author)
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Berk, Michael (author)
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Bøen, Erlend (author)
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Bonnin, Caterina Del Mar (author)
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Breuer, Fabian (author)
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Brosch, Katharina (author)
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Brouwer, Rachel M (author)
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Canales-Rodríguez, Erick J (author)
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Cannon, Dara M (author)
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Chye, Yann (author)
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Dahl, Andreas (author)
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Dandash, Orwa (author)
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Dannlowski, Udo (author)
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Dohm, Katharina (author)
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Elvsåshagen, Torbjørn (author)
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Fisch, Lukas (author)
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Fullerton, Janice M (author)
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Goikolea, Jose M (author)
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Grotegerd, Dominik (author)
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Haatveit, Beathe (author)
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Hahn, Tim (author)
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Hajek, Tomas (author)
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Heindel, Walter (author)
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- Ingvar, Martin (author)
- Karolinska Institutet
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Sim, Kang (author)
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Kircher, Tilo T J (author)
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Lenroot, Rhoshel K (author)
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Malt, Ulrik F (author)
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McDonald, Colm (author)
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McWhinney, Sean R (author)
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Melle, Ingrid (author)
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Meller, Tina (author)
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Melloni, Elisa M T (author)
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Mitchell, Philip B (author)
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Nabulsi, Leila (author)
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Nenadić, Igor (author)
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Opel, Nils (author)
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Overs, Bronwyn J (author)
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Panicalli, Francesco (author)
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Pfarr, Julia-Katharina (author)
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Poletti, Sara (author)
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Pomarol-Clotet, Edith (author)
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- Radua, Joaquim (author)
- Karolinska Institutet
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Repple, Jonathan (author)
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Ringwald, Kai G (author)
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Roberts, Gloria (author)
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Rodriguez-Cano, Elena (author)
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Salvador, Raymond (author)
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Sarink, Kelvin (author)
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Sarró, Salvador (author)
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Schmitt, Simon (author)
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Stein, Frederike (author)
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Suo, Chao (author)
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Thomopoulos, Sophia I (author)
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Tronchin, Giulia (author)
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Vieta, Eduard (author)
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Westlye, Lars T (author)
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White, Adam G (author)
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Yatham, Lakshmi N (author)
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Zak, Nathalia (author)
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Thompson, Paul M (author)
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Andreassen, Ole A (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 91:6, s. 582-592
- Related links:
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http://www.biologica...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD.Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables.Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Abé, Christoph
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Ching, Christoph ...
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Liberg, Benny
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Lebedev, Alexand ...
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Agartz, Ingrid
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Akudjedu, Theoph ...
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show more...
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Alda, Martin
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Alnæs, Dag
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Alonso-Lana, Sil ...
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Benedetti, Franc ...
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Berk, Michael
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Bøen, Erlend
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Bonnin, Caterina ...
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Breuer, Fabian
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Brosch, Katharin ...
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Brouwer, Rachel ...
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Canales-Rodrígue ...
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Cannon, Dara M
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Chye, Yann
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Dahl, Andreas
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Dandash, Orwa
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Dannlowski, Udo
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Dohm, Katharina
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Elvsåshagen, Tor ...
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Fisch, Lukas
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Fullerton, Janic ...
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Goikolea, Jose M
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Grotegerd, Domin ...
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Haatveit, Beathe
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Hahn, Tim
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Hajek, Tomas
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Heindel, Walter
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Ingvar, Martin
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Sim, Kang
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Kircher, Tilo T ...
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Lenroot, Rhoshel ...
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Malt, Ulrik F
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McDonald, Colm
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McWhinney, Sean ...
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Melle, Ingrid
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Meller, Tina
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Melloni, Elisa M ...
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Mitchell, Philip ...
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Nabulsi, Leila
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Nenadić, Igor
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Opel, Nils
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Overs, Bronwyn J
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Panicalli, Franc ...
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Pfarr, Julia-Kat ...
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Poletti, Sara
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Pomarol-Clotet, ...
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Radua, Joaquim
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Repple, Jonathan
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Ringwald, Kai G
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Roberts, Gloria
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Rodriguez-Cano, ...
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Salvador, Raymon ...
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Sarink, Kelvin
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Sarró, Salvador
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Schmitt, Simon
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Stein, Frederike
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Suo, Chao
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Thomopoulos, Sop ...
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Tronchin, Giulia
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Vieta, Eduard
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Westlye, Lars T
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White, Adam G
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Yatham, Lakshmi ...
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Zak, Nathalia
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Thompson, Paul M
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Andreassen, Ole ...
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Landén, Mikael, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Biological psych ...
- By the university
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University of Gothenburg
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Karolinska Institutet