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- Looi, Jeffrey C. L. (author)
Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Elsevier BV,2011
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:9d58e32b-1333-431e-a2a6-e6a9ddeedd2a
- https://lup.lub.lu.se/record/2227455URI
- https://doi.org/10.1016/j.pscychresns.2011.07.013DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by gait and postural disturbance, gaze palsy, apathy, decreased verbal fluency and dysexecutive symptoms, with some of these clinical features potentially having origins in degeneration of frontostriatal circuits and the mesencephalon. This hypothesis was investigated by manual segmentation of the caudate and putamen on MRI scans, using previously published protocols, in 15 subjects with PSP and 15 healthy age-matched controls. Midbrain atrophy was assessed by measurement of mid-sagittal area of the midbrain and pons. Shape analysis of the caudate and putamen was performed using spherical harmonics (SPHARM-PDM, University of North Carolina). The sagittal pons area/midbrain area ratio (P/M ratio) was significantly higher in the PSP group, consistent with previous findings. Significantly smaller striatal volumes were found in the PSP group - putamina were 10% smaller and caudate volumes were 17% smaller than in controls after controlling for age and intracranial volume. Shape analysis revealed significant shape deflation in PSP in the striatum, compared to controls; with regionally significant change relevant to frontostriatal and corticostriatal circuits in the caudate. Thus, in a clinically diagnosed and biomarker-confirmed cohort with early PSP, we demonstrate that neostriatal volume and shape are significantly reduced in vivo. The findings suggest a neostriatal and mesencephalic structural basis for the clinical features of PSP leading to frontostriatal and mesocortical-striatal circuit disruption. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- Neostriatum
- Caudate
- Putamen
- Mesencephalon
- Magnetic resonance imaging
Added entries (persons, corporate bodies, meetings, titles ...)
- Macfarlane, Matthew D. (author)
- Walterfang, Mark (author)
- Styner, Martin (author)
- Velakoulis, Dennis (author)
- Latt, JimmySkåne University Hospital(Swepub:lu)radf-jla (author)
- van Westen, DanielleLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups(Swepub:lu)ront-dva (author)
- Nilsson, ChristerLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-cni (author)
- Skåne University HospitalDiagnostisk radiologi, Lund (creator_code:org_t)
Related titles
- In:Psychiatry Research: Neuroimaging: Elsevier BV194:2, s. 163-1750925-4927
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