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  • Turner, Martin R (author)

Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-02-09
  • Springer Science and Business Media LLC,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-25723
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25723URI
  • https://doi.org/10.1007/s00415-006-0482-7DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Four PLS patients underwent cerebral [(11)C]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group comparisons, both sporadic and homD90A ALS patients demonstrated relative decreases in anterior and orbito-frontal binding compared to PLS patients, suggesting that there may be differences in cortical vulnerability between phenotypic groups.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hammers, Alexander (author)
  • Al-Chalabi, Ammar (author)
  • Shaw, Christopher E (author)
  • Andersen, Peter MUmeå universitet,Neurologi (author)
  • Brooks, David J (author)
  • Leigh, P Nigel (author)
  • Umeå universitetNeurologi (creator_code:org_t)

Related titles

  • In:Journal of Neurology: Springer Science and Business Media LLC254:8, s. 1033-60340-53541432-1459

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