Cerebrospinal fluid protein reactions during non-neurological surgery.

• OBJECTIVE: To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. SUBJECTS AND METHODS: Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. RESULTS: Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (betaTP) remained unchanged. CONCLUSIONS: Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Aged

Aged

80 and over

Arthroplasty

Replacement

Knee

adverse effects

Cerebrospinal Fluid Proteins

metabolism

Female

Humans

Intramolecular Oxidoreductases

blood

cerebrospinal fluid

Intraoperative Period

Lipocalins

Male

Middle Aged

Postoperative Period

Serum Albumin

metabolism

Stress

Physiological

blood

cerebrospinal fluid

etiology

beta 2-Microglobulin

blood

cerebrospinal fluid

spinal anaesthesia

stress

inflammation

fluid

cerebrospinal

blood-brain barrier

albumin

beta-2-microglobuline

Albumin

MEDICINE

Publication and Content Type

ref (subject category)

art (subject category)