Streptokinase activates plasminogen bound to human group C and group G streptococci through M-like proteins

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Fältnamn	Indikatorer	Metadata
000		04089naa a2200361 4500
001		oai:lup.lub.lu.se:98dd8cd9-724d-4011-88c3-190f2295781b
003		SwePub
008		160401s1994 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:3ff84f2f-6d00-4ea4-93a6-c4143ac1f165
024	7	a https://lup.lub.lu.se/record/310972 URI
024	7	a https://lup.lub.lu.se/record/12166062 URI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ben Nasr, Abdelhakim4 aut
245	1 0	a Streptokinase activates plasminogen bound to human group C and group G streptococci through M-like proteins
264	1	c 1994
520		a An ability to interact with plasminogen or plasmin could provide micro-organisms with a mechanism for invasion. Thus, group A, C and G streptococci secrete streptokinase which binds and activates plasminogen. Some streptococci also express surface structures which bind plasminogen without causing its activation. Plasminogen-binding surface proteins were extracted from one group C and one group G streptococcal isolate. Both proteins were found to bind plasmin, fibrinogen and serum albumin in addition to plasminogen. Gene fragments encoding the streptococcal proteins were amplified by PCR and were subsequently cloned and expressed in Escherichia coli. DNA sequence determination revealed for both genes open reading frames encoding proteins which contained repetitive domains and a carboxyl-terminal unrepeated region that were typical of M and M-like proteins. Though the amino-terminal regions of the group C and G streptococcal proteins demonstrated a rather high overall similarity between themselves, they were not similar to the variable regions of other M-like proteins with one exception: there was a 46% identity between the first 22 amino acids of the group G streptococcal protein and the corresponding sequence of PAM, the plasminogen-binding M-like protein of type M53 group A streptococci. Like the proteins extracted from the streptococci, the recombinant proteins bound plasminogen, fibrinogen and albumin. The three plasma proteins bound to separate sites on the streptococcal M-like proteins. Plasminogen bound by the group C and G streptococcal proteins was readily activated by streptokinase, providing evidence for a functional link between the secreted plasminogen-activator and proteins exposed on the bacterial surface.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
700	1	a Wistedt, Annika4 aut
700	1	a Ringdahl, Ulrikau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)mmb-uri
700	1	a Sjöbring, Ulfu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-usj
710	2	a Institutionen för immunteknologib Institutioner vid LTH4 org
773	0	t European Journal of Biochemistryg 222:2, s. 76-267q 222:2<76-267x 0014-2956
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/8020466x freey FULLTEXT
856	4	u http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1994.tb18865.x/abstractx freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/31097
856	4 8	u https://lup.lub.lu.se/record/1216606

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Av författaren/redakt...: Ben Nasr, Abdelh ...; Wistedt, Annika; Ringdahl, Ulrika; Sjöbring, Ulf

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Immunologi inom ...

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Av lärosätet: Lunds universitet

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