Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

Nilsson, Emma ALund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups (author)

Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown if epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and non-diabetic controls and related epigenetic alterations to gene expression and circulating folate levels.

Matte, Ashok (author)
Perfilyev, AlexanderLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-apy (author)
de Mello, Vanessa D (author)
Käkelä, Pirjo (author)
Pihlajamäki, Jussi (author)
Ling, CharlotteLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)endo-cl0 (author)
Diabetes - epigenetikForskargrupper vid Lunds universitet (creator_code:org_t)

In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society100:11, s. 1491-15011945-71970021-972X

By the author/editor: Nilsson, Emma A; Matte, Ashok; Perfilyev, Alexa ...; de Mello, Vaness ...; Käkelä, Pirjo; Pihlajamäki, Jus ...; show more...; Ling, Charlotte; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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