Sökning: onr:"swepub:oai:DiVA.org:du-28533" > Endothelial dysfunc...
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000 | 05872naa a2200613 4500 | |
001 | oai:DiVA.org:du-28533 | |
003 | SwePub | |
008 | 181001s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-363419 | |
009 | oai:prod.swepub.kib.ki.se:139244362 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-285332 URI |
024 | 7 | a https://doi.org/10.1016/j.rmed.2018.09.0092 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3634192 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1392443622 URI |
040 | a (SwePub)dud (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rydell, Andreasu Karolinska Institutet4 aut |
245 | 1 0 | a Endothelial dysfunction is associated with impaired lung function in two independent community cohorts |
264 | 1 | b Elsevier BV,c 2018 |
338 | a print2 rdacarrier | |
520 | a BackgroundPrior studies investigating the association between endothelial dysfunction and impaired lung function have been small and inconsistent. The primary aim was to investigate the association between endothelial function and lung function in two community-based cohorts.MethodsWe used a discovery/replication approach to study the association between endothelial function and lung function in the Prospective investigation of Obesity, Energy and Metabolism (POEM, discovery cohort, n = 490, mean age 50.3 ± 0.2 years) and the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, replication cohort, n = 892, mean age 70.2 ± 0.15 years). Spirometry and three different measures of endothelial function were performed including both the invasive forearm technique (endothelium-dependent and endothelium-independent vasodilation [EDV and EIDV, respectively] and noninvasive flow mediated dilation [FMD]).ResultsAn age and sex adjusted association between lower EDV and lower FEV1 was found in POEM and replicated in PIVUS. After merging the two cohorts, 1 standard deviation decrease in EDV was associated with 1.57% lower FEV1 after additional adjustment for smoking status, body mass index, exercise level, and C-reactive protein (95% confidence intervals 0.63–2.51, p = 0.001). The association was slightly lower albeit still statistically significant after excluding participants without cardiovascular disease and chronic respiratory disease and appeared stronger among previous/current smokers vs. non-smokers and in men vs. women (p for interaction = 0.2 and 0.02 respectively).ConclusionsOur findings suggest that even individuals with sub-clinical impairments of lung function in the community have concomitant endothelial dysfunction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Lung function | |
653 | a Endothelial function | |
653 | a Endothelial dependent vasodilation | |
653 | a Forced expiratory volume | |
653 | a Hälsa och välfärd | |
653 | a Health and Welfare | |
700 | 1 | a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn |
700 | 1 | a Lisspers, Karin,c Docent,d 1954-u Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)kalis120 |
700 | 1 | a Ställberg, Björn,c Docentu Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)bjsta623 |
700 | 1 | a Nowak, Christophu Karolinska Institutet4 aut |
700 | 1 | a Carlsson, Axel Cu Karolinska Institutet,Uppsala universitet,Lung- allergi- och sömnforskning,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden4 aut0 (Swepub:uu)axeca883 |
700 | 1 | a Feldreich, Tobiasu Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden4 aut |
700 | 1 | a Iggman, Davidu Uppsala universitet,Klinisk nutrition och metabolism,Norslund Svardsjo Primary Hlth Care Ctr, Dalarna Cty Council, Falun, Sweden4 aut0 (Swepub:uu)davig338 |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden;Norslund Svardsjo Primary Hlth Care Ctr, Dalarna Cty Council, Falun, Sweden4 aut0 (Swepub:du)jan |
710 | 2 | a Karolinska Institutetb Lung- allergi- och sömnforskning4 org |
773 | 0 | t Respiratory Medicined : Elsevier BVg 143, s. 123-128q 143<123-128x 0954-6111x 1532-3064 |
856 | 4 | u http://www.resmedjournal.com/article/S0954611118302919/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-28533 |
856 | 4 8 | u https://doi.org/10.1016/j.rmed.2018.09.009 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363419 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139244362 |
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