Sökning: onr:"swepub:oai:DiVA.org:hh-48898" >
Chronic Active Arth...
Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells : A Novel Experimental Model of Rheumatoid Arthritis
-
- Hagert, C. (författare)
- University of Turku, Turku, Finland
-
- Sareila, O. (författare)
- Karolinska Institutet
-
- Kelkka, T. (författare)
- The National Doctoral Programme in Informational and Structural Biology, Turku, Finland; University of Turku, Turku, Finland
-
visa fler...
-
- Nandakumar, Kutty Selva, 1965- (författare)
- Karolinska Institutet
-
- Collin, Mattias (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups,Lund University, Lund, Sweden
-
- Xu, B. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
-
- Guerard, S. (författare)
- Karolinska Institute,Karolinska Institute, Stockholm, Sweden
-
- Bäcklund, Johan (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
-
- Jalkanen, S. (författare)
- University of Turku, Turku, Finland
-
- Holmdahl, Rikard (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2018-06-20
- 2018
- Engelska.
-
Ingår i: Arthritis & Rheumatology. - Hoboken : Wiley. - 2326-5191 .- 2326-5205 .- 1529-0131. ; 70:8, s. 1343-1353
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To develop a new chronic rheumatoid arthritis model that is driven by the innate immune system. METHODS: Injection of a cocktail of 4 monoclonal antibodies against type II collagen, followed on days 5 and 60 by intraperitoneal injections of mannan (from Saccharomyces cerevisiae), was used to induce development of chronic arthritis in B10.Q mice. The role of the innate immune system as compared to the adaptive immune system in this arthritis model was investigated using genetically modified mouse strains. RESULTS: A new model of chronic relapsing arthritis was characterized in B10.Q mice, in which a persistently active, chronic disease was found. This relapsing disease was driven by macrophages lacking the ability to mount a reactive oxygen species response against pathogens, and was associated with the classical/alternative pathway, but not the lectin pathway, of complement activation. The disease was independent of Fcgamma receptor type III, and also independent of the activity of adaptive immune cells (B and T cells), indicating that the innate immune system, involving complement activation, could be the sole driver of chronicity. CONCLUSION: Chronic active arthritis can be driven innately by macrophages without the involvement of T and B cells in the adaptive immune system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Animals
- Antibodies
- Monoclonal/immunology
- Arthritis
- Experimental/*immunology
- Arthritis
- Rheumatoid/*immunology
- B-Lymphocytes/immunology
- Collagen Type II/immunology
- Disease Models
- Animal
- Immunity
- Innate/*immunology
- Macrophages/*immunology
- Mice
- T-Lymphocytes/*immunology
- Journal Article
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hagert, C.
-
Sareila, O.
-
Kelkka, T.
-
Nandakumar, Kutt ...
-
Collin, Mattias
-
Xu, B.
-
visa fler...
-
Guerard, S.
-
Bäcklund, Johan
-
Jalkanen, S.
-
Holmdahl, Rikard
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Arthritis & Rheu ...
- Av lärosätet
-
Högskolan i Halmstad
-
Lunds universitet
-
Karolinska Institutet